Fig. 6: SDT protects beta cells by suppressing mitochondrial dysfunction and inflammation through mitophagy. | Cell Death & Disease

Fig. 6: SDT protects beta cells by suppressing mitochondrial dysfunction and inflammation through mitophagy.

From: Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy

Fig. 6

a The recovery of Δψm by SDT was attenuated by CsA. Scale bar = 100 μm. Date are shown in b as the ratio of red-fluorescent cell number to green-fluorescent cell number. n = 4. cf The inhibition of mitochondrial ROS production by SDT was abolished by CsA. ROS was detected at 24 h post SDT. n = 3. g, h The downregulation of proinflammatory cytokine levels and IL-1β secretion was abrogated by CsA. n = 3. i SDT ameliorated the defective insulin secretion from PA injured beta cells. However, this favorable effect was blocked by PK11195 or CsA. Insulin secretion was evaluated by GSIS test. n = 3. Representative images are shown. Bars = Mean ± SEM

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