Fig. 6: Mitotic phosphorylation of SET isoform 1 is required for cell proliferation and anchorage-independent growth. | Cell Death & Disease

Fig. 6: Mitotic phosphorylation of SET isoform 1 is required for cell proliferation and anchorage-independent growth.

From: Cyclin-dependent kinase 1-mediated phosphorylation of SET at serine 7 is essential for its oncogenic activity

Fig. 6

Mitotic phosphorylation of SET isoform 1 is required for cell proliferation and anchorage-independent growth. a, b Cell proliferation curves of cell lines established in Figs. 3a (HeLa) and 4c (RKO). Data were expressed as the mean ± SD of three independent experiments. ***p < 0.001; **p < 0.01 (unpaired Student’s t test). Green asterisks mark comparisons between shControl and shSET groups. Red asterisks mark comparisons between isoform 1 SET-WT and SET-S7A groups. ce Anchorage-independent growth (colony formation assays in soft agar) of cell lines established in Figs. 3a (HeLa) and 4c (RKO). Data were expressed as the mean ± SD of three independent experiments. ***p < 0.001 (unpaired Student’s t test)

Back to article page