Fig. 3: SET8 promoted glucose uptake and tumorigenicity in vivo. | Cell Death & Disease

Fig. 3: SET8 promoted glucose uptake and tumorigenicity in vivo.

From: Monomethyltransferase SET8 facilitates hepatocellular carcinoma growth by enhancing aerobic glycolysis

Fig. 3

a, b Tumor growth following subcutaneous injection in the right flanks of Balb/c nude mice with 97H control cells, 97H-shSET8 cells, or 97H-SET8 cells (n = 5). c Immunostaining of Ki-67 in xenograft tissues. d Mice were imaged 60 min following intravenous (i.v.) injection of 18F-FDG by microPET/CT. Mice were fasted one night before detection. e Ratio of SUVmax of labeled 18F-FDG incorporation in the control group, shSET8 group, and SET8 group. f Immunostaining of SET8 and key glycolytic genes in tumors from the control group, shSET8 group, and SET8 group. g Cell apoptosis in xenograft tissues by TUNEL assay. Representative images of the immunostainings at ×20 magnification are shown. Scale bar, 50 μm

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