Fig. 1: Effect of α-synuclein (α-syn) and rotenone (Rot) on striatal rat slices. | Cell Death & Disease

Fig. 1: Effect of α-synuclein (α-syn) and rotenone (Rot) on striatal rat slices.

From: Selective inhibition of mitochondrial sodium-calcium exchanger protects striatal neurons from α-synuclein plus rotenone induced toxicity

Fig. 1

a Time-course graph showing the field excitatory postsynaptic field potential (fEPSP) amplitude measured in striatal slices before (pre-drug) and following 3 nM α-syn (n = 5, filled symbols) or 0.3 µM Rot (n = 10, open symbols) applied for 40 min. The traces show field potentials recorded before (pre-drug) and 40 min after 3 nM α-syn or 0.3 µM Rot. b Time course of the fEPSP amplitude measured before and following 0.3 µM Rot applied for 40 min (n = 10, open symbols) and before and following 0.3 µM Rot in slices incubated for 1 h with 3 nM α-syn (n = 13, filled symbols) (two-way analysis of variance (ANOVA), group main factor, F(1, 32) = 19.79, ***P < 0.0001). The traces show field potentials recorded before and 40 min after 0.3 µM Rot in a striatal slice incubated for 1 h with 3 nM α-syn

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