Fig. 2: Hsa_circ_001783 is up-regulated and correlated with poor clinical outcomes in breast cancer patients. | Cell Death & Disease

Fig. 2: Hsa_circ_001783 is up-regulated and correlated with poor clinical outcomes in breast cancer patients.

From: Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p

Fig. 2

a The cellular location and relative expression of hsa_circ_001783 in breast cancer tissue and adjacent non-cancerous tissue. The nuclear was stained with DAPI for blue color and hsa_circ_001783 was stained for red color. Scale bar, 20 μm. b The level of hsa_circ_001783 in breast cancer tissue compared to paired non-cancerous tissue (n = 18) analyzed by FISH. ***P < 0.001 compared to the level of hsa_circ_001783 in paired breast cancer tissue. c The expression of hsa_circ_001783 in frozen fresh breast cancer samples analyzed by qPCR (TNBC n = 11, Luminal/HER2+ n = 39). d The corresponding Ki-67 staining of breast cancer samples which has been used for FISH analysis. Scale bar, 20 μm. e The box plot of Ki-67 index in high and low hsa_circ_001783 subgroups. P = 0.009 compared to the Ki-67 in low hsa_circ_001783. Chi-square test was performed to analyze correlation between hsa_circ_001783 and Ki-67. X2 = 7.119, P = 0.008. f The disease-free survival (DFS) curves of 136 breast cancer patients with high or low hsa_circ_001783 expression. ER estrogen receptor, PR progesterone receptor, HER2 human epidermal growth factor receptor 2

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