Fig. 4: Ameliorative effects of IL-38 administration on pathological changes of IMQ-induced psoriasiform murine skin lesions. | Cell Death & Disease

Fig. 4: Ameliorative effects of IL-38 administration on pathological changes of IMQ-induced psoriasiform murine skin lesions.

From: IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment

Fig. 4

a Macroscopic views of back skin from mice left untreated (IMQ-) (i), IMQ-treated (IMQ + ) (ii) or co-treated with IMQ and IL-38 (IMQ + /IL-38) (iii) or IMQ and IL-36Ra (IMQ + /IL-36Ra) (iv), both subcutaneously injected, after 5 days. b Representative H&E staining of untreated (i), treated with IMQ cream (ii), in presence of IL-38 (iii) or IL-36Ra (iv). Bars, 500 μm. Subcutaneous injection of IL-38 or IL-36Ra reverted the phenotypic skin changes determined by IMQ. The quantifications of epidermal c, scale thickness d, and immune cell influx e were analyzed as parameters of skin acanthosis and inflammation. Graphs show means of microns of epidermis and stratum corneum thickness, and mean of number of infiltrating immune cells per section (n= 3 sections) ± S.D. per group (n = 8 mice). p* ≤ 0.01 and **p ≤ 0.001 compared with untreated or IMQ-treated groups, as assessed by unpaired Student‘s t test

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