Fig. 4: Additional phenotypic changes in mtDNA-depleter mice | Cell Death & Disease

Fig. 4: Additional phenotypic changes in mtDNA-depleter mice

From: Reversing wrinkled skin and hair loss in mice by restoring mitochondrial function

Fig. 4

a mtDNA-depleter mice demonstrate a very strong alopecia and wrinkled skin (i), kyphosis (ii), progeroid head (iii), and darkly pigmented ear pinnae (iv) phenotypic changes after induction with dox. b Representative images of a mtDNA-depleter mouse showing the gross phenotypic changes in the size and appearance compared to age-matched wild-type control littermate. c, d The different patterns of hair loss in male (c) and female (d) mtDNA-depleter mice. e Representative images showing gradual time-dependent phenotypic changes in skin wrinkles and hair loss in a female mtDNA-depleter mouse after continuous dox induction (i–iv)