Fig. 7: Working model of the role of TRIM50 in HCC progression. | Cell Death & Disease

Fig. 7: Working model of the role of TRIM50 in HCC progression.

From: TRIM50 suppressed hepatocarcinoma progression through directly targeting SNAIL for ubiquitous degradation

Fig. 7

TRIM50 was significantly downregulated in HCC cells and its decreased expression further promoted HCC progression. Further investigation showed that TRIM50 could target SNAIL for K-48 linked poly-ubiquitous degradation and thus reversed SNAIL-mediated epithelial-to-mesenchymal transition (EMT) transition. Altogether, loss of TRIM50 in HCC cells led to upregulation of EMT process and further promoted the malignant behaviors of HCC cells, including proliferation, colony formation, anoikis resistance, and invasion, thus promoted HCC progression