Fig. 6: BAP1 expression and copy number alterations in neuroblastoma patients and cell lines. | Cell Death & Disease

Fig. 6: BAP1 expression and copy number alterations in neuroblastoma patients and cell lines.

From: BAP1 induces cell death via interaction with 14-3-3 in neuroblastoma

Fig. 6

a, b BAP1 (P = 0.14) and Bax (P = 0.229) expression is associated with good outcome. Kaplan–Meier analysis using published array data from 102 patients with stage 4, non-MYCN amplified neuroblastoma. c Box plots showing the Log2 transformed expression profiles of BAP1 NB cohorts divided by COG Risk category (Intermediate risk patients were excluded). Left panel: BAP1 expression in the TARGET-NBL data set. Right panel: BAP1 expression in GSE73517 data. Gene expression data were downloaded from R2: Genomics Analysis and Visualization Platform (http://r2.amc.nl) and plotted using the R environment. Statistical significance was assessed by ANOVA test. d Whole-genome aberration plot of the six cell lines from the GEO series GSE89968 (in blue) are reported chromosomal losses and (in red) chromosomal gains, as well as the diploid regions in white. The black box highlights chromosome 3. e Zoomed-in view of chromosome 3 indicating altered regions. f Copy number alteration profile for chromosome 3 of SK-N-Be2c, SK-N-Be2c, and SK-N-DZ. LogR: log ratio values, BAF: B allele frequencies. The plots in d, e show deletion of BAP1 locus

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