Fig. 4: The expression of Gal-1 alters the genome-wide binding pattern of FOXP3. | Cell Death & Disease

Fig. 4: The expression of Gal-1 alters the genome-wide binding pattern of FOXP3.

From: Nuclear galectin-1-FOXP3 interaction dampens the tumor-suppressive properties of FOXP3 in breast cancer

Fig. 4

a Schematic overview of the breast cancer cell sample preparation for ChIP-Seq analysis. FOXP3-MDA-MB-231 cells were transfected with Gal-1 or empty vector before chromatin immunoprecipitation. b Genomic distributions of FOXP3 peaks in FOXP3-MDA-MB-231 cells transfected with Gal-1 or empty vector. c Heat maps of FOXP3 binding with FOXP3-MDA-MB-231 cells transfected with Gal-1 or empty vector. Each line on the y-axis represents a genomic region flanking the FOXP3 peak. d KEGG analysis of FOXP3-bound genes in FOXP3-MDA-MB-231 cells transfected with empty vector. e KEGG analysis of FOXP3-bound genes in FOXP3-MDA-MB-231 cells transfected with Gal-1

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