Table 2 Effect of HOTTIP on SCLC cell resistance index

From: Long non-coding RNA HOTTIP promotes BCL-2 expression and induces chemoresistance in small cell lung cancer by sponging miR-216a

  IC50 (μg/ml ±S)
Cell groups ADM CDDP VP-16
H69AR/si-HOTTIP 25.33 ± 5.51 29.0 ± 3.606 119.3 ± 15.01
 H69AR/si-NC 52.0 ± 9.17 56.0 ± 11.53 216.67 ± 10.69
 H69AR 45.67 ± 7.77 61.33 ± 16.50 237.3 ± 12.50
H446AR/si-HOTTIP 28.67 ± 6.51 46.33 ± 10.69 128.3 ± 2.89
 H446AR/si-NC 104.67 ± 15.5 135.33 ± 5.69 337.67 ± 52.3
 H446AR 98.33 ± 11.5 144.3 ± 10.07 292.33 ± 11.24
H69/pcDNA3.1+HOTTIP 75.33 ± 8.50 87.3 ± 3.51 229.00 ± 16.52
 H69/pcDNA3.1+NC 25.67 ± 5.03 33.0 ± 7.21 134.33 ± 6.02
 H69 19.0 ± 2.0 32.0 ± 3.0 161.33 ± 12.06
H446/pcDNA3.1+HOTTIP 117.3 ± 18.2 145.67 ± 7.09 214.33 ± 8.15
 H446/pcDNA3.1+NC 45.0 ± 6.0 53.33 ± 12.42 105.0 ± 22.72
 H446 42.3 ± 4.51 55.67 ± 11.06 111.67 ± 10.41
  1. ADM adriamycin, CDDP cisplatin, VP-16 etoposide