Fig. 5: Effects of ARRB1 and ARRB2 depletion on inflammation in macrophages. | Cell Death & Differentiation

Fig. 5: Effects of ARRB1 and ARRB2 depletion on inflammation in macrophages.

From: Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3

Fig. 5

a and b Levels of pro-inflammatory gene in ARRB1 and ARRB2 knockout BMDMs with or without LPS plus IFN-γ stimulation for 6 h. cf iNOS expression in ARRB1 and ARRB2 knockout BMDMs after stimulation for 24 h. g and h IL-6, IL-1β, and TNF-α expression in supernatants of ARRB1 and ARRB2 knockout BMDMs after stimulation for 24 h. il CD16 expression detected by immunofluorescence. Scale bars, 50 μm. Quantitative data are mean ± s.e. (n = 3). *P < 0.05, **P < 0.01, and ***P < 0.001.

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