Fig. 3 | Cell Death & Differentiation

Fig. 3

From: βarrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1

Fig. 3

53BP1 protein expression directly correlates with cell survival. a 53BP1 was either overexpressed or downregulated in MEF cells obtaining a range of different expression levels of the protein. Data are mean ± s.e.m of three independent experiments. b The clonogenicity assay images corresponding to 4 Gy irradiation. c Clonogenic cell survival analysis in MEF cells revealed a significant difference in survival after exposure to IR in the conditions tested; bar graph for 4 Gy (**p < 0.01 compare with WT). Data are mean ± s.e.m of an experiment run n = 6. d Fractional survival plot as a function of 53BP1 protein expression levels (r = 0.85)

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