Table 1 Differentially expressed miRNAs predicted to be p53-regulated in TP53-mutated and TP53 wild-type breast cancers

From: A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness

miRNA predicted to be regulated by p53a Transactivation scorea LOG2 fold changeb P-valuec
miR-146a 3 1.2 2.1E−07
let-7i 3 0.5 1.6E−06
miR-671 4 0.6 1.9E−06
miR-30a 3 -0.8 8.5E−06
miR-138-2 3 3.1 1.9E−04
miR-138-1 4 3.7 3.6E−04
miR-15b 3 0.8 4.8E−04
miR-615 3 0.8 5.6E−04
miR-9-2 3 2.4 2.0E−03
miR-196a-2 3 0.6 9.2E−03
miR-181a-1 3 0.3 1.0E−02
miR-191 4 0.4 1.3E−02
miR-328 4 0.3 3.4E−02
miR-490 3 2.1 9.4E−02
miR-194-1 3 0.2 1.1E−01
miR-302b 4 ND 2.3E−01
miR-34a 3 0.2 2.4E−01
miR-135a-2 3 –1.6 2.6E−01
miR-153-2 3 –0.3 3.9E−01
miR-1-1 3 –3.0 4.5E−01
miR-124-3 4 1.2 5.0E−01
miR-100 3 0.1 7.2E−01
miR-29b-2 3 0.0 8.3E−01
  1. aTransactivation score as calculated by Gowrisankar and Jegga [15]
  2. bData are reported as LOG2 fold change between TP53-mutated (82 cases) and wild-type (163 cases) breast cancers (TCGA series; strands from the same miRNA were jointly analyzed)
  3. cThe top 13 miRNAs were differentially expressed (p < 0.05) in TP53-mutated vs wild-type breast cancers