Fig. 5 | Cell Death & Differentiation

Fig. 5

From: A p53/miR-30a/ZEB2 axis controls triple negative breast cancer aggressiveness

Fig. 5

The p53/miR-30a/ZEB2 axis impinges upon miR-200c. a miR-200c levels in MDA231, MDA157 and HBL100 cell lines engineered to express miR-30a (5p/3p) or silenced for ZEB2 (sh1-ZEB2; sh2-ZEB2). Control vectors (pLenti6GFP and shGFP) yielded similar values and are here represented once as ctr. miR-200c levels in HBL100 ctr were set to 1. b miR-200c levels in MDA231 proficient (shGFP) or deficient (sh1-ZEB2, sh2-ZEB2) for ZEB2 expression, in the absence (ctr, pLenti6GFP) or presence (miR-30a-5p/3p) of ectopic miR-30a; *p < 0.05. c A unifying model of the new p53/miR-30a/ZEB2 axis (highlighted in bold) involved in TNBC

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