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How do thymic epithelial cells die?

Cell Death & Differentiationvolume 25pages10021004 (2018) | Download Citation

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References

  1. 1.

    Gabler J, et al. Promiscuous gene expression and the developmental dynamics of medullary thymic epithelial cells. Eur J Immunol. 2007;37:3363–72.

  2. 2.

    Gray D, et al. Proliferative arrest and rapid turnover of thymic epithelial cells expressing Aire. J Exp Med. 2007;204:2521–8.

  3. 3.

    Jain R, et al. A critical epithelial survival axis regulated by MCL-1 maintains thymic function in mice. Blood. 2017;130:2504–15.

  4. 4.

    Nedjic J, et al. Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance. Nature. 2008;455:396–400.

  5. 5.

    Metzger TC, et al. Lineage tracing and cell ablation identify a post-Aire-expressing thymic epithelial cell population. Cell Rep. 2013;5:166–79.

  6. 6.

    Wang X, et al. Post-Aire maturation of thymic medullary epithelial cells involves selective expression of keratinocyte-specific autoantigens. Front Immunol. 2012;3:19.

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Acknowledgements

We gratefully acknowledge the Gray, Strasser and Herold labs for valuable feedback. We thank the WEHI Flow Cytometry Laboratory for technical assistance; B Helbert, K Mackwell, C Young, C Hall for mouse genotyping; G Siciliano, K Humphreys, S O’Connor and H Marks for animal husbandry; S Korsmeyer for Baxlox/loxBak−/−, R Hakem for Casp8lox/lox, GA Holländer for Foxn1Cre and J Silke for Casp8−/−Ripk3−/− mice. This work was supported by grants GNT0637353, GNT1049724 and GNT1121325 and Career Development Fellowship-2 1090236 (for D.H.D.G.), 1016701 and Senior Principal Research Fellow [SPRF] Fellowship 1020363 (for A.S) from the Australian National Health and Medical Research Council and MIRS and MIFRS (for R.J.) from the University of Melbourne.

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Author notes

    • Reema Jain

    Present address: Program in Immunology, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, USA

Affiliations

  1. Walter and Eliza Hall Institute of Medical Research, Melbourne, VIC, Australia

    • Reema Jain
    • , Iris Tan
    • , Grant Dewson
    • , Andreas Strasser
    •  & Daniel H. D. Gray
  2. Department of Medical Biology, University of Melbourne, Melbourne, VIC, Australia

    • Reema Jain
    • , Iris Tan
    • , Grant Dewson
    • , Andreas Strasser
    •  & Daniel H. D. Gray
  3. Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, Melbourne, VIC, Australia

    • Justine D. Mintern

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Contributions

Conceptualization, R.J., A.S. and D.H.D.G.; Methodology, R.J, A.S. and D.H.D.G.; Investigation, R.J., G.D., I.T. and D.H.D.G.; Resources, J.D.M., A.S., D.H.D.G.; Writing–Original draft, R.J. and D.H.D.G.; Writing–Review and Editing, R.J., J.D.M., G.D., A.S. and D.H.D.G.

Conflict of interest

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Daniel H. D. Gray.

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DOI

https://doi.org/10.1038/s41418-018-0093-8