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LIPG: an inflammation and cancer modulator

Abstract

Endothelial lipase (LIPG/EL) performs fundamental and vital roles in the human body, including cell composition, cytokine expression, and energy provision. Since LIPG predominantly functions as a phospholipase as well as presents low levels of triglyceride lipase activity, it plays an essential role in lipoprotein metabolism, and involves in the metabolic syndromes such as inflammatory response and atherosclerosis. Cytokines significantly affect LIPG expression in endothelial cells in many diseases. Recently, it is suggested that LIPG contributes to cancer initiation and progression, and LIPG attached increasing importance to its potential for future targeted therapy.

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Fig. 1: Dynamic forms of LIPG in human body.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (No. 81672441), the Natural Science Foundation of Guangdong Province, China (Nos. 2016A030313580, 2017A030313607).

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Correspondence to Jie Lin.

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Hong, C., Deng, R., Wang, P. et al. LIPG: an inflammation and cancer modulator. Cancer Gene Ther 28, 27–32 (2021). https://doi.org/10.1038/s41417-020-0188-5

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