Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a relatively new class of antidiabetic drugs with demonstrated renal and cardiovascular disease benefit. This study evaluates the role of SGLT2 inhibitors on the survival of non-small cell lung cancer (NSCLC) patients.
We used National Surveillance, Epidemiology and End Results (SEER)-Medicare linked data. Twenty four thousand nine hundred fifteen NSCLC patients newly diagnosed between 2014 and 2017 with pre-exiting diabetes and aged 66 years or older were included and followed to the end of 2019. Information on SGLT2 inhibitors use was extracted from the Medicare Part D file.
SGLT2 inhibitor use was associated with significantly reduced mortality risk after adjusting for potential confounders (HR = 0.68, 95% CI = 0.60–0.77) with stronger association for longer duration of use (HR = 0.54, 85% CI = 0.44–0.68). Further, we found that SGLT2 inhibitor use was associated with a significant reduced risk of mortality regardless of patients’ demographic, tumour characteristics and cancer treatments.
Our large SEER-Medicare linked data study indicates that SGLT2 inhibitors use was associated with improved overall survival of NSCLC patients with pre-existing diabetes. Further studies are needed to confirm our findings and elucidate the possible mechanisms behind the association.
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Data were available from the SEER-Medicare website (https://healthcaredelivery.cancer.gov/seermedicare/obtain/) on reasonable request.
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This study is supported by the National Institutes of Health (R03CA256238).
The authors declare no competing interests.
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The study was reviewed and approved by the Human Research Protection Program (HRPP) Office of Research Compliance—Indiana University, Protocol #: 2012984604.
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Luo, J., Hendryx, M. & Dong, Y. Sodium-glucose cotransporter 2 (SGLT2) inhibitors and non-small cell lung cancer survival. Br J Cancer (2023). https://doi.org/10.1038/s41416-023-02177-2