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Cellular and Molecular Biology

Comment on ‘Use the term “infiltrative” instead of “replacement” when defining histopathological growth pattern in patients with liver cancer’ by Kong B et al.

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Fig. 1: Haematoxylin- and eosin-stained tissue section of a breast cancer liver metastasis with a replacement histopathological growth pattern (scale bar: 50 µm).


  1. Kong B, Zhang Q, Zhang G. Use the term “infiltrative” instead of “replacement” when defining histopathological growth pattern in patients with liver cancer. Br J Cancer. 2023 (this issue).

  2. Latacz E, Höppener D, Bohlok A, Leduc S, Tabariès S, Fernández Moro C, et al. Histopathological growth patterns of liver metastasis: updated consensus guidelines for pattern scoring, perspectives and recent mechanistic insights. Br J Cancer. 2022;127:988–1013.

    Article  PubMed  Google Scholar 

  3. Vermeulen PB, Colpaert C, Salgado R, Royers R, Hellemans H, Van Den Heuvel E, et al. Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J Pathol. 2001;195:336–42.

    Article  CAS  PubMed  Google Scholar 

  4. Bohlok A, Vermeulen P, Leduc S, Latacz E, Botzenhart L, Richard F, et al. Association between the histopathological growth patterns of liver metastases and survival after hepatic surgery in breast cancer patients. npj Breast Cancer. 2020;6:64.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Bridgeman VL, Vermeulen PB, Foo S, Bilecz A, Daley F, Kostaras E, et al. Vessel co-option is common in human lung metastases and mediates resistance to anti-angiogenic therapy in preclinical lung metastasis models. J Pathol. 2017;241:362–74.

    Article  CAS  PubMed  Google Scholar 

  6. Matsumoto K, Yoshitomi H, Rossant J, Zaret KS. Liver organogenesis promoted by endothelial cells prior to vascular function. Science. 2001;294:559–63.

    Article  CAS  PubMed  Google Scholar 

  7. Teuwen LA, De Rooij LPMH, Cuypers A, Rohlenova K, Dumas SJ, García-Caballero M, et al. Tumor vessel co-option probed by single-cell analysis. Cell Rep. 2021;35:109253.

    Article  CAS  PubMed  Google Scholar 

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The research projects of PV and LD are funded by the Koning Boudewijnstichting (King Baudouin Foundation)—Fonds Oncologie Augustinus.

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Correspondence to Peter Vermeulen.

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Vermeulen, P., Latacz, E., Hendrickx, L. et al. Comment on ‘Use the term “infiltrative” instead of “replacement” when defining histopathological growth pattern in patients with liver cancer’ by Kong B et al.. Br J Cancer 128, 705–706 (2023).

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