Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cellular and Molecular Biology

Comment on: “Evolving roles of CD38 metabolism in solid tumour microenvironment”

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Data availability

Not applicable.


  1. Gao L, Du X, Li J, Xiao-Feng Qin F. Evolving roles of CD38 metabolism in solid tumour microenvironment. Br J Cancer. 2022.

  2. Zocchi E, Franco L, Guida L, Calder L, De Flora A. Self-aggregation of purified and membrane-bound erythrocyte CD38 induces extensive decrease of its ADP-ribosyl cyclase activity. FEBS Lett. 1995;359:35–40.

    Article  CAS  PubMed  Google Scholar 

  3. Takasawa S, Tohgo A, Noguchi N, Koguma T, Nata K, Sugimoto T, et al. Synthesis and hydrolysis of cyclic ADP-ribose by human leukocyte antigen CD38 and inhibition of the hydrolysis by ATP. J Biol Chem. 1993;268:26052–4.

    Article  CAS  PubMed  Google Scholar 

  4. Tohgo A, Munakata H, Takasawa S, Nata K, Akiyama T, Hayashi N, et al. Lysine 129 of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) participates in the binding of ATP to inhibit the cyclic ADP-ribose hydrolase. J Biol Chem. 1997;272:3879–82.

    Article  CAS  PubMed  Google Scholar 

  5. Okamoto H, Takasawa S. Recent advances in the Okamoto model: the CD38-cyclic ADP-ribose signal system and the regenerating gene protein (Reg)-Reg receptor system in β-cells. Diabetes. 2002;51:S462–73.

    Article  CAS  PubMed  Google Scholar 

  6. Takasawa S. CD38–cyclic ADP-ribose signal system in physiology, biochemistry, and pathophysiology. Int J Mol Sci. 2022;23:4306.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations



PN was the single author.

Corresponding author

Correspondence to Pavel Nesmiyanov.

Ethics declarations

Competing interests

The author declares no competing interests.

Ethics approval and consent to participate

Not applicable.

Consent to publish

Not applicable.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Nesmiyanov, P. Comment on: “Evolving roles of CD38 metabolism in solid tumour microenvironment”. Br J Cancer 128, 491 (2023).

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI:


Quick links