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Clinical Studies

Validation of a novel risk score to predict early and late recurrence in solitary fibrous tumour



Current risk models in solitary fibrous tumour (SFT) were developed using cohorts with short follow-up and cannot reliably identify low-risk patients. We recently developed a novel risk model (G-score) to account for both early and late recurrences. Here, we aimed to validate the G-score in a large international cohort with long-term follow-up.


Data were collected from nine sarcoma referral centres worldwide. Recurrence-free interval (RFi) was the primary endpoint.


The cohort comprised 318 patients with localised extrameningeal SFTs. Disease recurrence occurred in 96 patients (33%). The estimated 5-year RFi rate was 72%, and the 10-year RFi rate was 52%. G-score precisely predicted recurrence risk with estimated 10-year RFi rate of 84% in low risk, 54% in intermediate risk and 36% in high risk (p < 0.001; C-index 0.691). The mDemicco (p < 0.001; C-index 0.749) and SalasOS (p < 0.001; C-index 0.674) models also predicted RFi but identified low-risk patients less accurate with 10-year RFi rates of 72% and 70%, respectively.


G-score is a highly significant predictor of early and late recurrence in SFT and is superior to other models to predict patients at low risk of relapse. A less intensive follow-up schedule could be considered for patients at low recurrence risk according to G-score.

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Fig. 1: Recurrence-free interval after surgery for localised, extrameningeal SFT.
Fig. 2: Prediction of recurrence risk using G-score, mDemicco and SalasOS.
Fig. 3: Correlation between risk stratification systems.

Data availability

The data are available from the corresponding author upon reasonable request.


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This work was supported by the Norwegian Cancer Society (grant number 144385-2014) and South-East Norway Regional Health Authority (grant number 2019064).

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Authors and Affiliations



TG collected and organised the data, performed data analysis, interpreted the results and drafted the manuscript; NAP, PS, YZ, AN, JVMGB, ÅH, GT, MS, MN, DS, TBH, RS, ACH, PH, DD, HKH, ML, JS, MAP, RLH, AMC, HL, NLJ, MS, RLJ, FH, IT and AS acquired and organised the data and revised the manuscript; LAMZ, FH and BB conceptualised the work and revised the manuscript; KB conceived, designed and guided the study, collected and organised the data, performed data analysis, interpreted the results and drafted the manuscript. All the authors have read the manuscript and agreed with the submission of the article in its present form.

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Correspondence to Kjetil Boye.

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The study was approved by the Regional Ethics Committee in South-East Norway (#2010-509) and conducted in accordance with the Declaration of Helsinki. All patients gave written informed consent to participate.

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Georgiesh, T., Aggerholm-Pedersen, N., Schöffski, P. et al. Validation of a novel risk score to predict early and late recurrence in solitary fibrous tumour. Br J Cancer 127, 1793–1798 (2022).

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