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Epidemiology

Association between physical activity and neoadjuvant chemotherapy completion and pathologic complete response in primary breast cancer: the CANTO study

British Journal of Cancer volume 127, pages 886–891 (2022)Cite this article

Subjects

Abstract

Background

Regular physical activity is associated with improved symptom control in patients with breast cancer but its association with chemotherapy completion or response is unclear.

Methods

Using a prospective design, 1075 breast cancer patients receiving neoadjuvant chemotherapy between March 2012 and February 2017 were studied. Physical activity was assessed using the Global Physical Activity Questionnaire [GPAQ-16], quantified in standardised MET-h/wk. Chemotherapy completion was defined as the proportion of patients completing planned treatment course, requiring dose reduction, or requiring dose delay. Response was evaluated by pathologic complete response (pCR). Associations between physical activity and primary outcomes were assessed using multivariable logistic regression models.

Results

There was no differences between any chemotherapy completion outcome on the basis of physical activity classification. The percent of patients not completing planned treatment was 5.7% for ≦0.33 MET-h/wk, compared with 6.8% for 0.34–16.65 MET-h/wk, and 4.6% for ≥16.6 MET-h/wk (p = 0.52). No significant relationships were observed between physical activity dose classification and pCR for the overall cohort or upon stratification by clinical subtype.

Conclusion

Future studies are required to further investigate the relationship between pre-treatment levels of physical activity and function on treatment completion and response in breast and other cancer populations.

Clinical trial registration

NCT01993498.

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Data availability

Data will be made available upon reasonable request.

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Acknowledgements

An interim analysis from this study was presented at the San Antonio Breast Cancer Symposium 2018, Dec 4–8, San Antonio, TX.

Funding

CANTO is funded by Agence Nationale de la Recherche (ANR-10-COHO-0004). IV-L received support from Odyssea, Foundation Gustave Roussy, and CCR17483507 Career Catalyst Research grant. ADM received support from Susan G. Komen, Clinical Research Fellowship from ESMO. LWJ is supported in part by funding from the National Cancer Institute, AKTIV Against Cancer, the KavliTrust, and the Memorial Sloan Kettering Cancer Center Support Grant/Core Grant (P30 CA008748).

Author information

Author notes

  1. These authors contributed equally: Ines Vaz-Luis, Lee W Jones.

Authors and Affiliations

  1. University of California Los Angeles, Los Angeles, CA, USA

    Jennifer L. Baker

  2. INSERM U 981 - Prédicteurs moléculaires et nouvelles cibles en oncologie, Institut Gustave Roussy, Villejuif, France

    Antonio Di Meglio, Arnauld S. Gbenou, Mayssam El Mouhebb, Andre Fabrice & Ines Vaz-Luis

  3. Memorial Sloan Kettering Cancer Center, New York City, NY, USA

    Neil M. Iyengar & Lee W. Jones

  4. Weill Cornell Medical College, New York, NY, USA

    Neil M. Iyengar & Lee W. Jones

  5. INSERM U1018 CESP, Service de Biostatistique et d’Epidemiologie, Institut Gustave Roussy, Villejuif, France

    Stefan Michiels

  6. Institut Curie, Paris, France

    Paul Cottu

  7. Institut Curie Saint Cloud, Saint Cloud, France

    Florence Lerebours & Patrick Arveux

  8. Centre Georges-Francois Leclerc, Dijon, France

    Charles Coutant

  9. Insitut de cancerlogie de Lorraine, Nancy, France

    Anne Lesur

  10. Centre Leon Berard, Lyon, France

    Oliver Tredan

  11. Centre Oscar Lambret, Lille, France

    Laurence Vanlemmens

  12. Institut de Cancérologie Jean Godinot, Reims, France

    Christelle Jouannaud

  13. Centre François Baclesse, Caen, France

    Iona Hrab

  14. UNICANCER, Paris, France

    Sibille Everhard & Anne-Laure Martin

  15. Medical Oncology Department, Institut Gustave Roussy, Villejuif, France

    Andre Fabrice & Ines Vaz-Luis

Authors
  1. Jennifer L. Baker
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  2. Antonio Di Meglio
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  3. Arnauld S. Gbenou
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  4. Mayssam El Mouhebb
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  5. Neil M. Iyengar
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  6. Stefan Michiels
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  7. Paul Cottu
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  8. Florence Lerebours
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  16. Anne-Laure Martin
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  19. Ines Vaz-Luis
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  20. Lee W. Jones
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Contributions

JLB: Wrote the paper. ADM, ASG, MEM: Conceived and designed the analysis and performed the analysis. NMI: Conceived and designed the analysis. SM, PC, FL, CC, AL, OT, LV, CJ, IH, SE, A-LM, PA, AF: Collected the data. IV-L, LWJ: Conceived and designed the analysis and wrote the paper.

Corresponding authors

Correspondence to Ines Vaz-Luis or Lee W. Jones.

Ethics declarations

Competing interests

LWJ owns stock in Pacylex, Inc. and Illumisonics, Inc. IV-L reports personal fees from AstraZeneca, Kephren, Amgen, and Novartis. ADM reports personal fees from Thermo Fisher and grants from European Society for Medical Oncology (ESMO), fellowship support, outside the submitted work.

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Informed consent was obtained from all patients prior to study participation at each institution.

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Baker, J.L., Di Meglio, A., Gbenou, A.S. et al. Association between physical activity and neoadjuvant chemotherapy completion and pathologic complete response in primary breast cancer: the CANTO study. Br J Cancer 127, 886–891 (2022). https://doi.org/10.1038/s41416-022-01870-y

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