Table. 3 Association between physical activity, grip strength, sedentary behaviour and malignant melanoma stratified by UV sensitivity.

From: Association between physical activity, grip strength and sedentary behaviour with incidence of malignant melanoma: results from the UK Biobank

  Low UV sensitivitya High UV sensitivityb
  Cases HR (95% CI) p-value Cases HR (95% CI) p-value
Physical activity
  Overall 372 0.98 (0.87–1.10) 0.755 846 1.02 (0.95–1.10) 0.574
  Women 140 1.00 (0.83–1.20) 0.983 412 1.03 (0.93–1.14) 0.613
  Men 232 0.98 (0.84–1.13) 0.751 434 1.02 (0.92–1.13) 0.711
Grip strength
  Overall 372 1.29 (1.01–1.64) 0.043 846 1.03 (0.88–1.20) 0.743
  Women 140 1.07 (0.84–1.37) 0.559 412 0.99 (0.86–1.14) 0.862
  Men 232 1.22 (1.00–1.48) 0.050 434 1.05 (0.91–1.21) 0.488
Sedentary behaviour
  Overall 372 1.09 (0.96–1.24) 0.178 846 1.00 (0.92–1.10) 0.935
  Women 140 1.11 (0.92–1.35) 0.264 412 1.04 (0.93–1.17) 0.500
  Men 232 1.07 (0.92–1.25) 0.403 434 0.98 (0.87–1.10) 0.747
  1. Cox proportional hazards regression models with observed exposure and UV sensitivity and multiply imputed covariable data. Exposures (physical activity, grip strength, sedentary behaviour) were entered as continuous variables. Associations were modelled linearly and hazard ratios are shown for an interquartile range increase (i.e. 25–75th percentile):
  2. aLow UV sensitivity: UV sensitivity score < 4 (overall n = 149,261; women n = 66,721; men n = 82,540).
  3. Physical activity: increment of 2877/2720/2988 MET-minutes per week of MVPA (overall/women/men).
  4. Grip strength: increment of 17/8/12 kg (overall/women/men).
  5. Sedentary behaviour: increment of 3/2.5/3 h per day (overall/women/men).
  6. bHigh UV sensitivity: UV sensitivity score ≥ 4 (overall n = 191,494; women n = 106,909; men n = 84,585).
  7. Physical activity: increment of 2656/2532/2791.5 MET-minutes per week of MVPA (overall/women/men).
  8. Grip strength: increment of 16/8/11.5 kg (overall/women/men).
  9. Sedentary behaviour: increment of 3/2.5/3 h per day (overall/women/men).
  10. Models were adjusted for age (as time scale), study region (baseline hazard stratification), gender (only in the overall group), education, pack years, alcohol consumption, coffee consumption, height, time spent outdoors during summer, sunburn occasions during childhood, solarium use and seasonality. Models were also mutually adjusted for physical activity, grip strength and sedentary behaviour.