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The making of the glioblastoma classification

British Journal of Cancer volume 125, pages 4–6 (2021)Cite this article

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Summary

Classification of cancer should lead to informative patients’ stratification and selective therapeutic vulnerabilities. A pathway-based classification of glioblastoma uncovered a mitochondrial subtype with a unique sensitivity to inhibitors of oxidative phosphorylation. Precision targeting of cancer metabolism could provide therapeutic opportunities to a lethal neoplasm and be translated to other tumour types.

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Fig. 1: Four-group functional classification of glioblastoma.

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Authors and Affiliations

  1. Institute for Cancer Genetics, Columbia University Medical Center, New York, NY, USA

    Anna Lasorella & Antonio Iavarone

  2. Department of Pathology and Cell Biology, Columbia University Medical Center, New York, NY, USA

    Anna Lasorella & Antonio Iavarone

  3. Department of Pediatrics, Columbia University Medical Center, New York, NY, USA

    Anna Lasorella

  4. Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, NY, USA

    Anna Lasorella & Antonio Iavarone

  5. Department of Neurology, Columbia University Medical Center, New York, NY, USA

    Antonio Iavarone

Authors
  1. Anna Lasorella
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  2. Antonio Iavarone
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Contributions

A.I. and A.L. conceived and wrote this Comment article.

Corresponding author

Correspondence to Antonio Iavarone.

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Not applicable.

Data availability

Not applicable.

Competing interests

A.L. and A.I. are listed as inventors on patent applications filed by Columbia University related to the diagnostic and therapeutic applications of the functional classification described here.

Funding information

This work was supported by NIH R01CA101644, U54CA193313, R01CA131126 and R01CA239721 to A.L.; R01CA178546, U54CA193313, R01CA179044, R01CA190891, R01CA239698, and The Chemotherapy Foundation’s grant to A.I.

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Lasorella, A., Iavarone, A. The making of the glioblastoma classification. Br J Cancer 125, 4–6 (2021). https://doi.org/10.1038/s41416-021-01360-7

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  • DOI: https://doi.org/10.1038/s41416-021-01360-7

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