Classification of cancer should lead to informative patients’ stratification and selective therapeutic vulnerabilities. A pathway-based classification of glioblastoma uncovered a mitochondrial subtype with a unique sensitivity to inhibitors of oxidative phosphorylation. Precision targeting of cancer metabolism could provide therapeutic opportunities to a lethal neoplasm and be translated to other tumour types.
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Ethics approval and consent to participate
A.L. and A.I. are listed as inventors on patent applications filed by Columbia University related to the diagnostic and therapeutic applications of the functional classification described here.
This work was supported by NIH R01CA101644, U54CA193313, R01CA131126 and R01CA239721 to A.L.; R01CA178546, U54CA193313, R01CA179044, R01CA190891, R01CA239698, and The Chemotherapy Foundation’s grant to A.I.
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Lasorella, A., Iavarone, A. The making of the glioblastoma classification. Br J Cancer 125, 4–6 (2021). https://doi.org/10.1038/s41416-021-01360-7