Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Reply to Comment on “Supplemental breast cancer-screening ultrasonography in women with dense breasts: a systematic review and meta-analysis”

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Yuan, W. H., Hsu, H. C., Chen, Y. Y. & Wu, C. H. Supplemental breast cancer-screening ultrasonography in women with dense breasts: a systematic review and meta-analysis. Br. J. Cancer 123, 673–688 (2020).

    Article  Google Scholar 

  2. 2.

    Niell, B. L., Freer, P. E., Weinfurtner, R. J., Arleo, E. K. & Drukteinis, J. S. Screening for breast cancer. Radiol. Clin. North. Am. 55, 1145–1162 (2017).

    Article  Google Scholar 

  3. 3.

    Shermis, R. B., Redfern, R. E., Burns, J. & Kudrolli, H. Molecular breast imaging in breast cancer screening and problem solving. Radiographics 37, 1309–1606 (2017).

    Article  Google Scholar 

  4. 4.

    Burkett, B. J. & Hanemann, C. W. A review of supplemental screening ultrasound for breast cancer: certain populations of women with dense breast tissue may benefit. Acad. Radiol. 23, 1604–1609 (2016).

    Article  Google Scholar 

  5. 5.

    Sterne, J. A., Sutton, A. J., Ioannidis, J. P., Terrin, N., Jones, D. R., Lau, J. et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 343, d4002 (2011).

    Article  Google Scholar 

  6. 6.

    Ohuchi, N., Suzuki, A., Sobue, T., Kawai, M., Yamamoto, S., Zheng, Y. F. et al. Sensitivity and specificity of mammography and adjunctive ultrasonography to screen for breast cancer in the Japan Strategic Anti-cancer Randomized Trial (J-START): a randomised controlled trial. Lancet 387, 341–348 (2016).

    Article  Google Scholar 

  7. 7.

    Yang, L., Wang, S., Zhang, L., Sheng, C., Song, F., Wang, P. et al. Performance of ultrasonography screening for breast cancer: a systematic review and meta-analysis. BMC Cancer 20, 499 (2020).

    Article  Google Scholar 

  8. 8.

    Lee, J., Kim, K. W., Choi, S. H., Huh, J. & Park, S. H. Systematic review and meta-analysis of studies evaluating diagnostic test accuracy: a practical review for Clinical Researchers-Part II. Statistical Methods of Meta-Analysis. Korean J. Radiol. 16, 1188–1196 (2015).

    Article  Google Scholar 

  9. 9.

    Hövels, A. M., Heesakkers, R. A., Adang, E. M., Jager, G. J., Strum, S., Hoogeveen, Y. L. et al. The diagnostic accuracy of CT and MRI in the staging of pelvic lymph nodes in patients with prostate cancer: a meta-analysis. Clin. Radiol. 63, 387–395 (2008).

    Article  Google Scholar 

Download references


We thank Convergence CT, Taiwan to help statistical analysis.

Author information




W.H.Y. and H.C.H. participated in the conception, design and implementation of the study. W.H.Y. and H.C.H. participated in literature research. W.H.Y. wrote the paper. H.C.H. and C.H.W. revised the paper. W.H.Y. and H.C.H. guaranteed the integrity of the entire study, performed the statistical analysis and definition of intellectual content. All authors reviewed and approved the final paper.

Corresponding author

Correspondence to Wei-Hsin Yuan.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Consent to publish

Not applicable.

Data availability

All data generated within this study are available from the corresponding author on request.

Competing interests

The authors declare no competing interests.

Funding information


Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Yuan, WH., Hsu, HC. & Wu, CH. Reply to Comment on “Supplemental breast cancer-screening ultrasonography in women with dense breasts: a systematic review and meta-analysis”. Br J Cancer (2021).

Download citation


Quick links