Summary
Precision oncology has largely been driven by genomic profiling, but success so far has been limited. By combining genomic and proteomic analyses of tumours, proteogenomics holds promise in providing deeper mechanistic insights and generating therapeutic hypotheses to better match patients to targeted treatments than analysing each ‘ome in isolation.
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Personalised selection of experimental treatment in patients with advanced solid cancer is feasible using whole-genome sequencing
British Journal of Cancer Open Access 23 May 2022
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J.T.L. and B.Z. drafted and revised the paper and approved the final version for publication.
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This work was supported by grants U24 CA210954 from the National Cancer Institute (NCI) Clinical Proteomic Tumor Analysis Consortium (CPTAC), by a Cancer Prevention Institute of Texas (CPRIT) award RR160027, and by funding from the McNair Foundation. J.T.L is supported by grant T32 CA203690 from the Translational Breast Cancer Research Training Program. B.Z. is a CPRIT Scholar in Cancer Research and McNair Medical Institute Scholar.
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Lei, J.T., Zhang, B. Proteogenomics drives therapeutic hypothesis generation for precision oncology. Br J Cancer 125, 1–3 (2021). https://doi.org/10.1038/s41416-021-01346-5
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DOI: https://doi.org/10.1038/s41416-021-01346-5
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