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Targeting acetate metabolism: Achilles’ nightmare


Recent advances in our understanding of tumour heterogeneity alongside studies investigating altered metabolism within transformed tissue have identified metabolic pathways critical to cancer cell survival. Leveraging this information presents a promising new avenue for the generation of cancer-specific therapeutics and improved patient outcomes.

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Fig. 1: Targeting ACSS2 in human pathologies.


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K.D.M. and Z.T.S. generated the figures and wrote the manuscript.

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Correspondence to Zachary T. Schug.

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The authors declare no competing interests.

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This work was supported by grants from NIH NCI DP2 CA249950-01 (Z.T.S.), NIH NCI P01 CA114046-12, Susan G. Komen® CCR19608782 (Z.T.S.), the V Foundation for Cancer Research (Z.T.S.) and NIH NCI T32 CA009171-44 (K.D.M.).

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Miller, K.D., Schug, Z.T. Targeting acetate metabolism: Achilles’ nightmare. Br J Cancer 124, 1900–1901 (2021).

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