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Targeting acetate metabolism: Achilles’ nightmare

Summary

Recent advances in our understanding of tumour heterogeneity alongside studies investigating altered metabolism within transformed tissue have identified metabolic pathways critical to cancer cell survival. Leveraging this information presents a promising new avenue for the generation of cancer-specific therapeutics and improved patient outcomes.

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Fig. 1: Targeting ACSS2 in human pathologies.

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K.D.M. and Z.T.S. generated the figures and wrote the manuscript.

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Correspondence to Zachary T. Schug.

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The authors declare no competing interests.

Funding information

This work was supported by grants from NIH NCI DP2 CA249950-01 (Z.T.S.), NIH NCI P01 CA114046-12, Susan G. Komen® CCR19608782 (Z.T.S.), the V Foundation for Cancer Research (Z.T.S.) and NIH NCI T32 CA009171-44 (K.D.M.).

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Miller, K.D., Schug, Z.T. Targeting acetate metabolism: Achilles’ nightmare. Br J Cancer 124, 1900–1901 (2021). https://doi.org/10.1038/s41416-021-01345-6

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