We describe a potential role for thymidine kinase-1, a general marker of cellular proliferation, to act as a prognostic biomarker in patients receiving CDK4/6 inhibitors for advanced hormone receptor-positive, HER2-negative breast cancer, with early data suggesting that it may also provide early indication of treatment response.
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L.M. has received research support from Novartis and Pfizer and is a consultant for Eli Lilly, Pfizer, and Novartis. Both authors have academically collaborated with Biovica International without any financial remuneration or contractual agreement.
This work was partially supported by a grant from the Breast Cancer Research Foundation (grant number BCRF 19-037) and by a grant from Fondazione AIRC (IG 22869).
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McCartney, A., Malorni, L. Potential through simplicity: thymidine kinase-1 as a biomarker for CDK4/6 inhibitors. Br J Cancer 123, 176–177 (2020). https://doi.org/10.1038/s41416-020-0858-y