This nationwide study investigated associations between paternal occupational exposure and childhood bone tumours and soft- tissue sarcomas.
The UK National Registry of Childhood Tumours provided cases of childhood sarcomas born and diagnosed in Great Britain, 1962–2010. Control births, unaffected by childhood cancer, were matched on sex, birth period and birth registration sub-district. Fathers’ occupations were assigned to one or more of 33 exposure groups and coded for occupational social class.
We analysed 5,369 childhood sarcoma cases and 5380 controls. Total bone tumours, total soft-tissue sarcomas and the subgroups osteosarcoma, rhabdomyosarcoma and Ewing Sarcoma Family of Tumours (ESFT) were considered separately. Significant positive associations were seen between rhabdomyosarcoma and paternal exposure to EMFs (odds ratio = 1.67, CI = 1.22–2.28) and also for ESFT and textile dust (1.93, 1.01–3.63). There were putative protective effects on total bone tumours of paternal dermal exposure to hydrocarbons, metal, metal working or oil mists.
Despite the large size and freedom from bias of this study, our results should be interpreted with caution. Many significance tests were undertaken, and chance findings are to be expected. Nevertheless, our finding of associations between ESFT and paternal exposure to textile dust may support related suggestions in the literature.
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We acknowledge the major contributions made by Nicola Fear, Tom Keegan and Angela MacCarthy to earlier papers in this series. We are grateful to Janette King for her work on occupational coding and to Helen Elwell of BMA Library Services for conducting a computerised literature search on our behalf.
Ethics approval and consent to participate
Oxfordshire Research Ethics Committee (Oxfordshire REC C, Ref 12/SC/0532) approved the use of these data in 2012 without the need for individual subject consent.
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The data are contained within the National Registry of Childhood Tumours.
The authors declare no competing interests.
The work of the Childhood Cancer Research Group (CCRG) was supported by Children with Cancer UK, the Scottish Government and the Department of Health for England and Wales.
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Kendall, G.M., Bunch, K.J., Stiller, C.A. et al. Case–control study of paternal occupational exposures and childhood bone tumours and soft-tissue sarcomas in Great Britain, 1962–2010. Br J Cancer 122, 1250–1259 (2020). https://doi.org/10.1038/s41416-020-0760-7