Table 1 DCIS characteristics of the whole cohort stratified by treatment groups.

From: Pathological features of 11,337 patients with primary ductal carcinoma in situ (DCIS) and subsequent events: results from the UK Sloane Project

  BCS only BCS+RT BCS (RT unknown) Mx Total
DCIS grade
  Low 693 23.3% 114 2.5% 38 9.5% 151 4.5% 996 8.8%
  Intermediate 1371 46.2% 979 21.4% 118 29.6% 633 18.8% 3101 27.4%
  High 892 30.0% 3472 76.0% 239 60.1% 2591 76.7% 7194 63.6%
  Unknown 13 0.4% 2 0.0% 3 0.8% 1 0.0% 19 0.2%
DCIS architecture
  Solid 1356 45.7% 3098 67.8% 240 60.3% 2183 64.7% 6877 60.8%
  Cribriform 1709 57.6% 2173 47.6% 182 45.7% 1721 51.0% 5785 51.1%
  Micropapillary 474 16.0% 554 12.1% 52 13.1% 774 22.9% 1854 16.4%
  Flat 133 4.5% 189 4.1% 20 5.0% 261 7.7% 603 5.3%
  Papillary 164 5.5% 168 3.7% 22 5.5% 153 4.5% 507 4.5%
  Apocrine 65 2.2% 89 1.9% 3 0.8% 93 2.8% 250 2.2%
  Other 23 0.8% 32 0.7% 3 0.8% 34 1.0% 92 0.8%
  Unknown 266 9.0% 393 8.6% 46 11.6% 267 7.9% 972 8.6%
Size of DCIS
  <10 mm 1553 52.3% 1025 22.4% 103 25.9% 198 5.9% 2879 25.5%
  10–20 mm 895 30.1% 1675 36.7% 150 37.7% 466 13.8% 3186 28.2%
  20–30 mm 276 9.3% 1078 23.6% 80 20.1% 545 16.1% 1979 17.5%
  30–4 mm 91 3.1% 443 9.7% 28 7.0% 509 15.1% 1071 9.5%
  >40 mm 59 2.0% 311 6.8% 27 6.8% 1592 47.2% 1989 17.6%
  No residual DCISa 68 2.3% 19 0.4% 6 1.5% 7 0.2% 100 0.9%
  Unknown 27 0.9% 16 0.4% 4 1.0% 59 1.7% 106 0.9%
Comedo necrosis
  Present 1097 36.9% 3211 70.3% 215 54.0% 2369 70.2% 6892 60.9%
  Absent 1552 52.3% 984 21.5% 105 26.4% 711 21.1% 3352 29.6%
  Unknown 320 10.8% 372 8.1% 78 19.6% 296 8.8% 1066 9.4%
Associated epithelial atypia (ADH or lobular neoplasia)
  Yes 500 16.8% 448 9.8% 40 10.1% 312 9.2% 1300 11.5%
  No 2469 83.2% 4119 90.2% 358 89.9% 3064 90.8% 10,010 88.5%
Microinvasion
  Present 82 2.8% 325 7.1% 19 4.8% 313 9.3% 739 6.5%
  Absent 2823 95.1% 4178 91.5% 344 86.4% 3018 89.4% 10,363 91.6%
  Unknown 64 2.2% 64 1.4% 35 8.8% 45 1.3% 208 1.8%
Margin width
  <2 mm 375 13% 644 14% 65 16%   0% 1084 10%
  ≥2 mm 2410 81% 3719 81% 259 65%   0% 6388 56%
  Unknown 184 6% 204 4% 74 19%   0% 462 4%
 Total number 2969 100% 4567 100% 398 100% 3376 100% 11,310 100%
  1. aNo residual DCIS in the surgical excision. Lesion was removed by previous core/vacuum-assisted biopsy.