Fig. 3 | British Journal of Cancer

Fig. 3

From: Drug sensitivity testing on patient-derived sarcoma cells predicts patient response to treatment and identifies c-Sarc inhibitors as active drugs for translocation sarcomas

Fig. 3

Alveolar soft part sarcoma patient-derived cells (K-ASPS2 and K-ASPS3). a Haematoxylin and eosin staining of formalin-fixed ASPS biopsies and the derived PDC (visualised by light microscopy). b Proximity ligation assay showing nuclear expression of the ASPS1-TFE3 fusion protein in the K-ASPS2 cells and cytoplasmic signals in K-ASPS3. Muscle cells as negative control. c Expression of cancer driver genes determined by Q-RT-PCRT in the K-ASPS3 relative to normal muscle cells. d Plot showing the drug activity in K-ASPS2 and e K-ASPS3 respectively. Patient treatment at the time of biopsy is highlighted in red

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