Fig. 1 | British Journal of Cancer

Fig. 1

From: Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment

Fig. 1

Insulin receptor (INSR) is overexpressed in tumour endothelial cells. a Overexpression of INSR in colorectal cancer (qPCR;9) and renal cell cancer (proteomics;55) associated endothelial cells. b Immunohistochemical staining for INSR on sections of different paraffin embedded human solid tumours (colon, kidney, stomach, breast, skin) and normal tissue counterparts. A clear induction of vascular staining (brown) is seen tumours (T) as compared to normal tissues (insets; N). Scale bars represent 50 μm. c Immunohistochemical staining for INSR of human head and neck squamous carcinoma tissue with adjacent normal tissue. Overexpression of INSR is related to malignancy as strong vascular staining is observed in the tumour, less pronounced staining in the intermediate area and absence of staining in the adjacent normal tissue. Arrows heads highlight the blood vessels. The scale bar represents 200 μm. d Kaplan–Meier survival analysis of 226 CRC cases based on average INSR expression

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