Fig. 2 | British Journal of Cancer

Fig. 2

From: Transcription factors WT1 and p53 combined: a prognostic biomarker in ovarian cancer

Fig. 2

Combinations of WT1 and p53 expression in invasive OvCa (×400). Expression of p53 was considered “Normal” when nuclei were variably stained and scattered positive nuclei were seen in more than 10% but less than 75% of nuclei (nuclear histoscore area × intensity p53 > 0.1 < 2.25). p53 expression was considered “Altered” when tumour cells were strongly positive 2+–3+ in 75–100% nuclei (abnormal uniform stain, upper image, nuclear histoscore area × intensity p53 = 2.25–2.7) or completely devoid of stain (abnormal loss lower image, nuclear histoscore area × intensity p53 = 0). WT1 was considered positive when 75–100% of nuclei expressed this transcription factor. Images illustrate the four combinations of expression of these two transcription factors and tumour-associated antigens

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