Larvin H, Kang J, Aggarwal V R, Pavitt S, Wu J. Systemic Multimorbidity Clusters in People with Periodontitis. J Dent Res 2022; DOI: 10.1177/00220345221098910. Online ahead of print.

People with periodontitis are more likely to present with hypertension and obesity together, and diabetes is more influential to multimorbidity clusters in people with severe periodontitis.

This study aimed to identify systemic multimorbidity clusters in people with periodontitis. Cross-sectional data of 3,736 participants across three cycles of the National Health and Nutrition Examination Survey (2009 to 2014) were utilised. Periodontal examination was carried out by trained dentists for participants aged ≥30 years. The extent of periodontitis was represented by the proportion of sites with clinical attachment loss (CAL)≥ 3 mm, split into four equal quartiles. A range of systemic diseases reported during the survey were also extracted. In the study population, the top three prevalent diseases were hypertension (63.9%), arthritis (47.6%) and obesity (45.9%). A total of 106 unique systemic multimorbidity clusters were identified. Hypertension was the most centralised disease in the overall population, followed closely by arthritis and obesity. 'Hypertension, obesity' was the largest weighted multimorbidity cluster across CAL quartiles.