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Preserving pulp vitality: part two - vital pulp therapies

Abstract

Vital pulp therapies (VPTs) aim to preserve the vitality of the pulp. The European Society of Endodontology have begun a campaign to raise awareness on the efficacy of VPTs following on from the publication of their 2019 position statement, aimed at both specialists and general dental practitioners. This review examines the current evidence surrounding VPTs and provides a rational approach to the management of the exposed pulp with the aid of case studies. Success lies in accurate diagnosis and case selection, along with well-executed treatment and appropriate follow-up protocols. The introduction of calcium silicate cements has made these treatments more predictable.

Key points

  • There is sufficient evidence to recommend calcium silicate cements ahead of calcium hydroxide for all vital pulp therapies, but consideration must be given to potential discolouration in material selection.

  • The main driver for a decision between different vital pulp therapies is the visual appearance of the pulp and the ability to control haemorrhage.

  • Following careful case selection, teeth receiving vital pulp therapies with calcium silicate cements have a good prognosis, equal to pulpectomy and root canal treatment, which still remains an option in the event of failure.

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References

  1. Trope M. Regenerative potential of dental pulp. J Endod 2008; 34(7 Suppl): S13-S17.

  2. Duncan H F, Galler K M, Tomson P L et al. European Society of Endodontology position statement: Management of deep caries and the exposed pulp. Int Endod J 2019; 52: 923-934.

  3. Aguilar P, Linsuwanont P. Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review. J Endod 2011; 37: 581-587.

  4. Cushley S, Duncan H F, Lappin M J et al. Pulpotomy for mature carious teeth with symptoms of irreversible pulpitis: A systematic review. J Dent 2019; 88: 103158.

  5. Li Y, Sui B, Dahl C et al. Pulpotomy for carious pulp exposures in permanent teeth: A systematic review and meta-analysis. J Dent 2019; 84: 1-8.

  6. Ng Y L, Mann V, Gulabivala K. A prospective study of the factors affecting outcomes of non-surgical root canal treatment: Part 1: Periapical health. Int Endod J 2011; 44: 583-609.

  7. Ng Y-L, Mann V, Gulabivala K. A prospective study of the factors affecting outcomes of non-surgical root canal treatment: part 2: tooth survival. Int Endod J 2011; 44: 610-625.

  8. Patel S, Durack C, Abella F et al. European Society of Endodontology position statement: The use of CBCT in Endodontics. Int Endod J 2014; 47: 502-504.

  9. American Association of Endodontists. Endodontic Diagnosis. 2013. Available at https://www.aae.org/specialty/wp-content/uploads/sites/2/2017/07/endodonticdiagnosisfall2013.pdf (accessed March 2020).

  10. Hashem D, Mannocci F, Patel S et al. Clinical and radiographic assessment of the efficacy of calcium silicate indirect pulp capping: a randomized controlled clinical trial. J Dent Res 2015; 94: 562-568.

  11. Wolters W J, Duncan H F, Tomson P L et al. Minimally invasive endodontics: a new diagnostic system for assessing pulpitis and subsequent treatment needs. Int Endod J 2017; 50: 825-829.

  12. Matsuo T, Nakanishi T, Shimizu H, Ebisu S. A clinical study of direct pulp capping applied to carious-exposed pulps. J Endod 1996; 22: 551-556.

  13. Bailey O, O'Connor C. Papilla management in sub-gingival, interproximal, direct composite restoration: A key concept to success. Br Dent J 2019; 226: 933-937.

  14. Bogen G, Kim J S, Bakland L K. Direct pulp capping with Mineral Trioxide Aggregate: An observational study. J Am Dent Assoc 2008; 139: 305-315.

  15. Caliskan M K, Guneri P. Prognostic factors in direct pulp capping with mineral trioxide aggregate or calcium hydroxide: 2-to 6-year follow-up. Clin Oral Investig 2017; 21: 357-367.

  16. Hilton T J, Ferracane J L, Mancl L. Comparison of CaOH with MTA for Direct Pulp Capping: A PBRN Randomized Clinical Trial. J Dent Res 2013; 92: S16-S22.

  17. Mente J, Geletneky B, Ohle M et al. Mineral trioxide aggregate or calcium hydroxide direct pulp capping: an analysis of the clinical treatment outcome. J Endod 2010; 36: 806-813.

  18. Murray P E, Hafez A A, Smith A J, Cox C F. Bacterial microleakage and pulp inflammation associated with various restorative materials. Dent Mater 2002; 18: 470-478.

  19. Kakahashi S, Stanley H S, Fitzgerald R J. The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg 1965; 20: 340-349.

  20. Farges J C, Alliot-Licht B, Renard E et al. Dental pulp defence and repair mechanisms in dental caries. Mediators Inflamm 2015; DOI: 10.1155/2015/230251.

  21. Stanley H R. Criteria for standardizing and increasing credibility of direct pulp capping studies. Am Dent J 1998; 1: 17-34.

  22. Li Z, Cao L, Fan M, Xu Q. Direct Pulp Capping with Calcium Hydroxide or Mineral Trioxide Aggregate: A meta-analysis. J Endod 2015; 41: 1412-1417.

  23. Dammaschke T, Leidinger J, Schafer E. Long-term evaluation of direct pulp capping-treatment outcomes over an average period of 6.1 years. Clin Oral Investig 2010; 14: 559-567.

  24. Mejàre I, Cvek M. Partial pulpotomy in young permanent teeth with deep carious lesions. Endod Dent Traumatol 1993; 9: 238-242.

  25. Chailertvanitkul P, Paphangkorakit J, Sooksantisakoonchai N et al. Randomized controlled trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars. Int Endod J 2014; 47: 835-842.

  26. Bogen G, Kim J S, Bakland L K. Direct pulp capping with mineral trioxide aggregate: an observational study. J Am Dent Assoc 2008; 139: 305-315.

  27. Parinyaprom N, Nirunsittirat A, Chuveera P. Outcomes of direct pulp capping using either ProRoot mineral trioxide aggregate or biodentine in permanent teeth with carious pulp exposure in 6-to 18-year-old patients: A randomized controlled trial. J Endod 2018; 44: 341-348.

  28. Schroder U. Effects of Calcium Hydroxide-containing Pulp-capping Agents on Pulp Cell Migration, Proliferation, and Differentiation. J Dent Res 1985; 64: 541-548.

  29. Hilton T J. Keys to clinical success with pulp capping: A review of the literature. Oper Dent 2009; 34: 615-625.

  30. Kundzina R, Stangvaltaite L, Eriksen H M, Kerosuo E. Capping carious exposures in adults: a randomized controlled trial investigating mineral trioxide aggregate versus calcium hydroxide. Int Endod J 2017; 50: 924-932.

  31. Grech L, Mallia B, Camilleri J. Investigation of the physical properties of tricalcium cilicate cement-based root-end filling materials. Dent Mater 2013; 29: 20-28.

  32. Mente J, Hufnagel S, Leo M et al. Treatment outcome of Minteral Trioxide Aggregate or Calcium Hydroxide Direct Pulp Capping: Long-term results. J Endod 2014; 40: 1746-1751.

  33. Marques M S, Wesselink P R, Shemesh H. Outcome of direct pulp capping with mineral trioxide aggregate: A prospective study. J Endod 2015; 41: 1026-1031.

  34. Suhag K, Duhan J, Tewari S, Sangwan P. Success of direct pulp capping using mineral trioxide aggregate and calcium hydroxide in mature permanent molars with pulps exposed during carious tissue removal: 1-year follow-up. J Endod 2019; 45: 840-847.

  35. Hermann B. Calcium hydroxyd als mitten zum behandeln und fullen von Wurzelkanallen. Würzburg: University of Würzburg, 1920. Dissertation.

  36. Cvek M. A clinical report on partial pulpotomy and capping with calcium hydroxide in permanent incisors with complicated crown fracture. J Endod 1978; 4: 232-237.

  37. Mcjare I, Cvek M. Partial pulpotomy in young permanent teeth with deep carious lesions. Endod Dent Traumatol 1993; 9: 238-242.

  38. Asgary S, Hassanizadeh R, Torabzadeh H, Eghbal M J. Treatment outcomes of 4 vital pulp therapies in mature molars. J Endod 2018; 44: 529-535.

  39. Asgary S, Eghbal M J, Bagheban A A. Long-term outcomes of pulpotomy in permanent teeth with irreversible pulpitis: A multi-centre randomized controlled trial. Am J Dent 2017; 30: 151-155.

  40. Asgary S, Eghbal M J. Treatment outcomes of pulpotomy in permanent molars with irreversible pulpitis using biomaterials: A multi-centre randomized controlled trial. Acta Odontol Scand 2013; 71: 335-341.

  41. Galani M, Tewari S, Sangwan P, Mittal S, Kumar V, Duhan J. Comparative evaluation of postoperative pain and success rate after pulpotomy and root canal treatment in cariously exposed mature permanent molars: A randomized controlled trial. J Endod 2017; 43: 1953-1962.

  42. Linsuwanont P, Wimonsutthikul K, Pothimoke U, Santiwong B. Treatment outcomes of mineral trioxide aggregate pulpotomy in vital permanent teeth with carious pulp exposure: The retrospective study. J Endod 2017; 43: 225-230.

  43. Taha N A, Khazali M A. Partial Pulpotomy in Mature Permanent Teeth with Clinical Signs Indicative of Irreversible Pulpitis: A Randomized Clinical Trial. J Endod 2017; 43: 1417-1421.

  44. Kang C M, Sun Y, Song J S et al. A randomized controlled trial of various MTA materials for partial pulpotomy in permanent teeth. J Dent 2017; 60: 8-13.

  45. Tan S Y, Yu V S H, Lim K C et al. Long-term pulpal and restorative outcomes of pulpotomy in mature permanent teeth. J Endod 2020; 46: 383-390.

  46. Asgary S, Eghbal M J, Fazlyab M, Baghban A A, Ghoddusi J. Five-year results of vital pulp therapy in permanent molars with irreversible pulpitis: A non-inferiority multicentre randomized clinical trial. Clin Oral Investig 2015; 19: 335-341.

  47. Kim D, Kim E. Antimicrobial effect of calcium hydroxide as an intracanal medicament in root canal treatment: a literature review - Part II. in vivo studies. Restor Dent Endod 2015; 40: 97-103.

  48. Prosser H J, Groffman D M, Wilson A D. The effect of composition on the erosion properties of calcium hydroxide cements. J Dent Res 1982; 61: 1431-1435.

  49. Pacios M G, Silva C, Lopez M E, Cecilia M. Antibacterial action of calcium hydroxide vehicles and calcium hydroxide pastes. J Investig Clin Dent 2012; 3: 264-270.

  50. Estrela C, Sidney G B, Bammann L L, Felipe Jr O. Mechanism of action of calcium and hydroxyl ions of calcium hydroxide on tissue and bacteria. Braz Dent J 1995; 6: 85-90.

  51. Accorinte L, Holland R, Reis A et al. Evaluation of mineral trioxide aggregate and calcium hydroxide cement as pulp-capping agents in human teeth. J Endod 2008; 34: 1-6.

  52. Tomson P L, Lumley P J, Smith A J, Cooper P R. Growth factor release from dentine matrix by pulp-capping agents promotes pulp tissue re-air-associated events. Int Endod J 2017; 50: 281-292.

  53. Tomson P L, Grover L M, Lumley P J, Sloan A J, Smith A J, Cooper P R. Dissolution of bio-active dentine matrix components by mineral trioxide aggregate. J Dent 2007; 35: 636-642.

  54. Eskandarizadeh A, Shahpasandzadeh M H, Shahpasandzadeh M, Torabi M, Parirokh M. A comparative study on dental pulp response to calcium hydroxide, white and grey mineral trioxide aggregate as pulp capping agents. J Conserv Dent 2011; 14: 351-355.

  55. Camilleri J, Montesin F E, Brady K, Sweeny R, Curtis R V, Pitt Ford T R. The constitution of mineral trioxide aggregate. Dent Mater 2005; 21: 297-303.

  56. Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review - Part I: chemical, physical, and antibacterial properties. J Endod 2010; 36: 16-27.

  57. Torabinejad M, Hong C U, Mcdonald F, Pitt Ford T R. Physical and chemical properties of a new root-end filling material. J Endod 1995; 21: 349-353.

  58. Al-Hezaimi K, Naghshbandi J, Oglesby S, Simon J H S, Rotstein I. Human saliva penetration of root canals obturated with two types of mineral trioxide aggregate cements. J Endod 2005; 31: 453-456.

  59. Ferk Luketic S, Malcic A, Jukic S, Anic I, Segovic S, Kalenic S. Coronal microleakage of two root-end filling materials using a polymicrobial marker. J Endod 2008; 34: 201-203.

  60. Aeinehchi M, Eslami B, Ghanbariha M, Saffar A S. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: a preliminary report. Int Endod J 2003; 36: 225-231.

  61. Nowicka A, Wilk G, Lipski M, Kolecki J, Buczkowska-Radlinska J. Tomographic evaluation of reparative dentine formation after direct pulp capping with Ca(OH)2, MTA, Biodentine, and dentine bonding system in human teeth. J Endod 2015; 41: 1234-1240.

  62. Min K, Park H, Lee S et al. Effect of mineral trioxide aggregate on dentin bridge formation and expression of dentin sialoprotein and haem oxygenase-1 in human dental pulp. J Endod 2008; 34: 666-670.

  63. Parolia A, Kundabala M, Rao N N et al. Comparative histological analysis of human pulp following direct pulp capping with Propolis, mineral trioxide aggregate and Dycal. Aust Dent J 2010; 55: 59-64.

  64. Sawicki L, Pameijer C, Emerich K, Adamowicz-Klepalska B. Histological evaluation of mineral trioxide aggregate and calcium hydroxide in direct pulp capping of human immature permanent teeth. Am J Dent 2008; 21: 262-266.

  65. Nair P N R, Duncan H F, Pitt ford T R, Luder H U. Histological, ultrastructural and quantitative investigations on the response of healthy human pulps to experimental capping with mineral trioxide aggregate: A randomized controlled trial. Int Endod J 2009; 42: 422-444.

  66. Swarup S J, Rao A, Boaz K, Srikant N, Shenoy R. Pulpal response to nano hydroxyapatite, mineral trioxide aggregate and calcium hydroxide when used as a direct pulp capping agent: an in vivo study. J Clin Pediatr Dent 2014; 38: 201-206.

  67. Kitasako Y, Ikeda M, Tagami J. Pulpal responses to bacterial contamination following dentin bridging beneath hard-setting calcium hydroxide and self-etching adhesive resin system. Dent Traumatol 2008; 24: 201-206.

  68. Willershausen B, Willershausen I, Ross A, Velikonja S, Kasaj A, Blettner M. Retrospective study on direct pulp capping with calcium hydroxide. Quintessence Int 2011; 42: 165-171.

  69. Barthel C R, Rosenkranz B, Leuenberg A, Roulet J F. Pulp capping of carious exposures: treatment outcome after 5 and 10 years: a retrospective study. J Endod 2000; 26: 525-528.

  70. Kaup M, Dammann C H, Schafer E, Dammaschke T. Shear bond strength of Biodentine, ProRoot MTA, glass ionomer cement and composite resin on human dentine ex vivo. Head Face Med 2015; 11: 14.

  71. Camilleri J. Staining potential of Neo MTA Plus, MTA Plus and Biodentine used for pulpotomy procedures. J Endod 2015; 41: 1139-1145.

  72. Keskin C, Demiryurek E O, Ozyurek T. Colour stabilities of calcium silicate-based materials in contact with different irrigation solutions. J Endod 2015; 41: 409-411.

  73. Beatty H, Svec T. Quantifying coronal tooth discolouration caused by Biodentine and EndoSequence root repair material. J Endod 2015; 41: 2036-2039.

  74. Marciano M A, Costa R M, Camilleri J, Mondelli R F, Guimarães B M, Duarte M A. Assessment of colour stability of white mineral trioxide aggregate angelus and bismuth oxide in contact with tooth structure. J Endod 2014; 40: 1235-1240.

  75. Edwards D C, Burns L, Witton R, Tredwin C. MTA or calcium hydroxide for direct pulp capping in fully developed permanent teeth: a systematic review. ENDO 2020; 14: 91-102.

  76. Schwendicke F, Brouwer F, Stolpe M. Calcium Hydroxide versus Mineral Trioxide Aggregate for Direct Pulp Capping: A Cost-effectiveness Analysis. J Endod 2015; 41: 1969-1974.

  77. Zhu C, Ju B, Ni R. Clinical outcome of direct pulp capping with MTA of calcium hydroxide: a systematic review and meta-analysis. Int J Clin Exp Med 2015; 8: 17055-17060.

  78. Akhlaghi N, Khademi A. Outcomes of vital pulp therapy in permanent teeth with different medicaments based on review of the literature. Dent Res J 2015; 12: 406-417.

  79. Awawdeh L, Al-Qudah A, Hamouri H, Chakra R J. Outcomes of vital pulp therapy using Mineral Trioxide Aggregate or Biodentine: A prospective randomised controlled trial. J Endod 2018; 44: 1603-1609.

  80. Kumar V, Juneja R, Duhan J, Sangwan P, Tewari S. Comparative evaluation of platelet-rich fibrin, mineral trioxide aggregate, and calcium hydroxide as pulpotomy agents in permanent molars with irreversible pulpitis: A randomized controlled trial. Contemp Clin Dent 2016; 7: 512-518.

  81. Özgür B, Uysal S, Güngör H C. Partial pulpotomy in immature permanent molars after carious exposures using different haemorrhage control and capping materials. Pediatr Dent 2017; 39: 364-370.

  82. Alqaderi H, Lee C T, Borzangy S, Pagonis T C. Coronal pulpotomy for cariously exposed permanent posterior teeth with closed apices: A systematic review and meta-analysis. J Dent 2016; 44: 1-7.

  83. Bjørndal L, Demant S, Dabelsteen S. Depth and activity of carious lesions as indicators for the regenerative potential of dental pulp after intervention. J Endod 2014; 40(4 Suppl): S76-S81.

  84. Horsted P, Sandergaard B, Thylstrup A, El Attar K, Fejerskov O. A retrospective study of direct pulp capping with calcium hydroxide compounds. Endod Dent Traumatol 1985; 1: 29-34.

  85. Al-Hiyasat A S, Barrieshi-Nusair K M, Al-Omari M A. The radiographic outcomes of direct pulp-capping procedures performed by dental students: a retrospective study. J Am Dent Assoc 2006; 137: 1699-1705.

  86. Cho S Y, Seo D G, Lee S J et al. Prognostic factors for clinical outcomes according to time after direct pulp capping. J Endod 2013; 39: 327-331.

  87. Bjørndal L, Fransson H, Bruun G et al. Randomized clinical trials on deep carious lesions: 5-year follow-up. J Dent Res 2017; 96: 747-753.

  88. Goodis H E, Kahn A, Simon S. Aging and the pulp. In Hargreaves K M, Goodis H E, Tay F R (eds) Seltzer and Bender's Dental Pulp. 2nd ed. Berlin: Quintessence, 2012.

  89. Ricketts D. Management of the deep carious lesion and the vital pulp dentine complex. Br Dent J 2001; 191: 606-610.

  90. Miles J P, Gluskin A H, Chambers D, Peters O A. Pulp capping with Mineral Trioxide Aggregate (MTA): a retrospective analysis of carious pulp exposures treated by undergraduate students. Oper Dent 2010; 35: 20-28.

  91. FGDP (UK). FGDP selection criteria for dental radiography standards. 2018. Available online at https://www.fgdp.org.uk/selection-criteria-dental-radiography (accessed January 2020).

  92. Hashem D, Mannocci F, Patel S, Manoharan A, Watson T F, Banerjee A. Evaluation of the efficacy of calcium silicate vs. glass ionomer cement indirect pulp capping and restoration assessment criteria: a randomised controlled clinical trial-2-year results. Clin Oral Investig 2019; 23: 1931-1939.

  93. Rushton V E. Justification of CBCT and guidelines for clinical use. 2011. Available at http://www.sedentexct.eu/system/files/Dr%20Rushton.pdf (accessed March 2020).

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Acknowledgements

Thank you to Luca Moranzoni and Jonathan Cowie for supplying the pictures of the clinical cases.

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Edwards, D., Stone, S., Bailey, O. et al. Preserving pulp vitality: part two - vital pulp therapies. Br Dent J 230, 148–155 (2021). https://doi.org/10.1038/s41415-020-2599-y

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