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Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil

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Fig. 1: Overall response in 20 patients (B-ALL: 13; B-NHL: 7) treated with CD19-directed CAR-T cell.

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The data presented in this report are available on request to the corresponding author.


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The authors thank Nathália Cristine André, Sandra Navarro Bresciani, Maristela Delgado Orellana, Lucas Botelho, Amanda Mizukami Martins, Taísa Risque Fernandes, Sâmia Rigotto Caruso, Virginia Picanço-Castro, and Patricia Bonini Vianna for their assistance. We also thank all the personnel involved in CAR-T cell manufacturing.


Fundação de Amparo à Pesquisa do Estado de São Paulo—FAPESP (process number 2013/08.135-2), São Paulo, Brazil. Butantan Institute, São Paulo, Brazil.

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Conceptualization: Camila D. Donadel, Gil C. De Santis, Renato Luiz Guerino-Cunha, Rodrigo T. Calado, Dimas T. Covas and Diego V. Clé; Methodology: Camila D. Donadel, Gil C. De Santis and Diego V. Clé; Statistical analysis: Thiago Eleutério Gonçalves, Camila D. Donadel and Gil C. De Santis; Data collection: Camila D. Donadel, Bruno G. Pires, Flavia Gava, Giancarlo Fatobene, Joana T. B. Faria, Gabriela V. A. Silva, Luiz Guilherme Darrigo-Junior, Renato Luiz Guerino-Cunha, and Thiago Eleutério Gonçalves; Writing—original draft preparation: Camila D. Donadel, Bruno G. Pires, Gil C. De Santis, Diego V. Clé; Writing—review and editing: Camila D. Donadel, Gil C. De Santis, Giancarlo Fatobene, Flavia Gava, Vanderson Rocha, Rodrigo T. Calado, Diego V. Clé. All authors have read and agreed to the published version of the paper.

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Correspondence to Camila D. Donadel.

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Donadel, C.D., De Santis, G.C., Gonçalves, T.E. et al. Safety and efficacy of a new academic CD19-directed CAR-T cell for refractory/relapsed non-Hodgkin lymphoma and acute lymphoblastic leukemia in Brazil. Bone Marrow Transplant (2024).

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