Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Effect of HLA mismatch on post-transplant infections in allogeneic hematopoietic stem cell transplantation with PTCy-based GvHD prophylaxis

Bone Marrow Transplantation volume 58, pages 1042–1044 (2023)Cite this article

Subjects

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

References

  1. Gu Z, Wang L, Yuan L, Huang W, Li M, Guan L, et al. Similar outcomes after haploidentical transplantation with post-transplant cyclophosphamide versus HLA-matched transplantation: a meta-analysis of case-control studies. Oncotarget. 2017;8:63574–86. www.impactjournals.com/oncotarget.

  2. Mikulska M, Raiola AM, Galaverna F, Balletto E, Borghesi ML, Varaldo R, et al. Pre-engraftment bloodstream infections after allogeneic hematopoietic cell transplantation: impact of T cell-replete transplantation from a haploidentical donor. Biol Blood Marrow Transplant. 2018;24:109–18. https://doi.org/10.1016/j.bbmt.2017.08.024.

    Article  PubMed  Google Scholar 

  3. Gooptu M, Romee R, St. Martin A, Arora M, Al Malki M, Antin JH, et al. HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis. Blood. 2021;138:273–82. https://doi.org/10.1182/blood.2021011281.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Galli E, Metafuni E, Giammarco S, Limongiello MA, Innocenti I, Autore F, et al. Triple post transplant cyclophosphamide (PTCY) based GVHD prophylaxis: HLA matched versus HLA haploidentical transplants. Bone Marrow Transplant. 2022;57:532–7. https://doi.org/10.1038/s41409-022-01574-0.

    Article  CAS  PubMed  Google Scholar 

  5. Peter Donnelly J, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, et al. Revision and update of the consensus definitions of invasive fungal disease from the european organization for research and treatment of cancer and the mycoses study group education and research consortium. Clin Infect Dis. 2020;71:1367–76. https://doi.org/10.1093/cid/ciz1008.

    Article  PubMed  Google Scholar 

  6. Scrucca L, Santucci A, Aversa F. Regression modeling of competing risk using R: an in depth guide for clinicians. Bone Marrow Transplant. 2010;45:1388–95. https://doi.org/10.1038/bmt.2009.359.

    Article  CAS  PubMed  Google Scholar 

  7. Rambaldi B, Kim HT, Reynolds C, Chamling Rai S, Arihara Y, Kubo T, et al. Impaired T- and NK-cell reconstitution after haploidentical HCT with posttransplant cyclophosphamide. Blood Adv. 2021;5:352–64. https://doi.org/10.1182/bloodadvances.2020003005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Esquirol A, Pascual MJ, Kwon M, Pérez A, Parody R, Ferra C, et al. Severe infections and infection-related mortality in a large series of haploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide. Bone Marrow Transplant. 2021;56:2432–44. https://doi.org/10.1038/s41409-021-01328-4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Oltolini C, Greco R, Galli L, Clerici D, Lorentino F, Xue E, et al. Infections after allogenic transplant with post-transplant cyclophosphamide: impact of donor HLA matching. Biol Blood Marrow Transplant. 2020;26:1179–88. https://doi.org/10.1016/j.bbmt.2020.01.013.

    Article  PubMed  Google Scholar 

  10. Irene GC, Albert E, Anna BV, Rahinatu A, Silvana N, Silvana S, et al. Patterns of infection and infectious-related mortality in patients receiving post-transplant high dose cyclophosphamide as graft-versus-host-disease prophylaxis: impact of HLA donor matching. Bone Marrow Transplant. 2021;56:818–27. https://doi.org/10.1038/s41409-020-01092-x.

    Article  CAS  PubMed  Google Scholar 

  11. Bashey A, Zhang MJ, Mccurdy SR, St Martin A, Argall T, Anasetti C, et al. Mobilized peripheral blood stem cells versus unstimulated bone marrow as a graft source for T-cell-replete haploidentical donor transplantation using post-transplant cyclophosphamide. J Clin Oncol. 2017;35:3002–9. https://doi.org/10.1200/JCO.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

This study was supported by Associazione Italiana Ricerca contro il Cancro (AIRC) grant to AB.

Author information

Authors and Affiliations

  1. Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Roma, Italy

    J. D. Marra, E. Galli, P. Chiusolo, F. Sora, L. Laurenti, A. Fresa, A. Bacigalupo & S. Sica

  2. Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

    E. Galli, S. Giammarco, P. Chiusolo, E. Metafuni, F. Sora, L. Laurenti, I. Innocenti, F. Autore, M. A. Limongiello, A. Fresa, A. Bacigalupo & S. Sica

Authors
  1. J. D. Marra
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Galli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Giammarco
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. P. Chiusolo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. Metafuni
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. F. Sora
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. L. Laurenti
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. I. Innocenti
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. F. Autore
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. M. A. Limongiello
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. A. Fresa
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. A. Bacigalupo
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. S. Sica
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

JDM and AB designed the study and drafted the paper. EG, SG, PC, EM, FS, LL, II, FA, MAL, AF, AB, and SS provided clinical data. EG, PC, and SS critically reviewed the paper.

Corresponding author

Correspondence to J. D. Marra.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Marra, J.D., Galli, E., Giammarco, S. et al. Effect of HLA mismatch on post-transplant infections in allogeneic hematopoietic stem cell transplantation with PTCy-based GvHD prophylaxis. Bone Marrow Transplant 58, 1042–1044 (2023). https://doi.org/10.1038/s41409-023-02010-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41409-023-02010-7

Search

Advanced search

Quick links