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Effect of HLA mismatch on post-transplant infections in allogeneic hematopoietic stem cell transplantation with PTCy-based GvHD prophylaxis

Bone Marrow Transplantation volume 58, pages 1042–1044 (2023)Cite this article

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Post-transplant cyclophosphamide (PTCy) has increased the use of haploidentical (HAPLO) donors [1] Early data associated HAPLO transplants with increased infections, though only HAPLO patients received PTCy [2]. In a registry-based study comparing HAPLO vs. MATCHED grafts with PTCy [3], there were increased bacterial infections and fungal infections in HAPLO transplants with myeloablative and reduced-intensity conditioning, respectively [3].

In the present study, we compared post-transplant infections in a cohort of patients with HAPLO or MATCHED donor and uniform PTCy-based immunosuppression.

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Data availability

The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

This study was supported by Associazione Italiana Ricerca contro il Cancro (AIRC) grant to AB.

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Authors and Affiliations

  1. Sezione di Ematologia, Dipartimento di Scienze Radiologiche ed Ematologiche, Università Cattolica del Sacro Cuore, Roma, Italy

    J. D. Marra, E. Galli, P. Chiusolo, F. Sora, L. Laurenti, A. Fresa, A. Bacigalupo & S. Sica

  2. Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy

    E. Galli, S. Giammarco, P. Chiusolo, E. Metafuni, F. Sora, L. Laurenti, I. Innocenti, F. Autore, M. A. Limongiello, A. Fresa, A. Bacigalupo & S. Sica

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  1. J. D. Marra
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  2. E. Galli
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  7. L. Laurenti
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  8. I. Innocenti
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  9. F. Autore
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  10. M. A. Limongiello
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  11. A. Fresa
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  13. S. Sica
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Contributions

JDM and AB designed the study and drafted the paper. EG, SG, PC, EM, FS, LL, II, FA, MAL, AF, AB, and SS provided clinical data. EG, PC, and SS critically reviewed the paper.

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Correspondence to J. D. Marra.

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Marra, J.D., Galli, E., Giammarco, S. et al. Effect of HLA mismatch on post-transplant infections in allogeneic hematopoietic stem cell transplantation with PTCy-based GvHD prophylaxis. Bone Marrow Transplant 58, 1042–1044 (2023). https://doi.org/10.1038/s41409-023-02010-7

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