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DNA methylation in circulating leukocytes is a novel biomarker in multiple myeloma

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Fig. 1: PBMC DNA methylation in patients with myeloma from the BMT CTN 0702 (STaMINA) phase 3 trial.

Data availability

The clinical data that support the findings of this study are publicly available at BioLINCC: Blood and Marrow Transplant Clinical Trials Network (BMT CTN) A Trial of Single Autologous Transplant With or Without Consolidation Therapy Versus Tandem Autologous Transplant With Lenalidomide Maintenance for Patients With Multiple Myeloma (0702) (nih.gov). DNA methylation data will be shared upon reasonable request with the corresponding author.

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Acknowledgements

This ancillary study was funded by a Froedtert & MCW Cancer Center grant (project 3379013). AD is supported by K23 HL141445. The BMT CTN 0702 was supported by Grant No. U10HL069294 to the Blood and Marrow Transplant Clinical Trials Network from the National Heart, Lung, and Blood Institute and the National Cancer Institute; by Celgene Corporation and Millennium (Takeda) Pharmaceuticals; and by The Alliance for Clinical Trials in Oncology, the Eastern Cooperative Oncology Group–American College of Radiology Imaging Network Cancer Research Group, and SWOG. The content of this article is solely the responsibility of the authors and does not represent the official views of the funding parties.

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AD designed the study, obtained funding, reviewed the analysis, and wrote the manuscript. RB designed and conducted the biostatistical analysis, and edited the manuscript. BQT conducted biostatistical analysis. GY, HU and SJ conducted the DNA methylation assays, reviewed the analysis, and edited the manuscript. JD and MBD reviewed the analysis and edited the manuscript. MCP (Protocol Officer, BMT CTN 0702), SG, HL, ES (Protocol Co-Chair, BMT CTN 0702), and AK (Protocol Co-Chair, BMT CTN 0702) led the BMT CTN 0702 study and/or were from the top 3 centers that provided data contributing to this study, reviewed the current analysis, and edited the manuscript. All authors approved the final manuscript draft.

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Correspondence to Anita D’Souza.

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D’Souza, A., Brazauskas, R., Teng, B.Q. et al. DNA methylation in circulating leukocytes is a novel biomarker in multiple myeloma. Bone Marrow Transplant (2022). https://doi.org/10.1038/s41409-022-01887-0

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