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Hyponatremia induced by post-transplant cyclophosphamide in allogeneic hematopoietic cell transplantation

Bone Marrow Transplantation volume 58, pages 212–214 (2023)Cite this article

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TO THE EDITOR:

The use of post-transplant-cyclophosphamide (PTCy) for graft-versus-host-disease (GVHD) prophylaxis is becoming widespread in patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) [1]. As a response to the emergent number of publications reporting the efficacy and safety derived from the use of cyclophosphamide (Cy) for GVHD prevention, this letter aims to share some new results on a complication from this use.

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Data availability

Data supporting this study’s findings would be available on request from the corresponding author [MQS].

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Acknowledgements

We thank our patients and the nursing and support staff in the Hematopoietic Cell Transplant Program and the Nephrology Medical Department at Hospital Clinic de Barcelona.

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Authors and Affiliations

  1. Hematopoietic Transplantation Unit, Hematology Department, Clinical Institute of Hematology and Oncology (ICMHO), Hospital Clínic de Barcelona, Barcelona, Spain

    Marta Gómez-Hernando, María Suárez-Lledo, Nuria Martínez-Cibrian, Andrea Rivero, Anna Serrahima, Maria Teresa Solano, Laura Rosiñol, Jordi Esteve, Alvaro Urbano-Ispizua, Francesc Fernández-Avilés, Carmen Martínez, Montserrat Rovira & Maria Queralt Salas

  2. Clinical Nephrology Section, Nephrology and Renal Transplantation Department, Hospital Clínic de Barcelona, ICNU, Barcelona, Spain

    Luis F. Quintana

  3. Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Luis F. Quintana, María Suárez-Lledo, Nuria Martínez-Cibrian, Andrea Rivero, Laura Rosiñol, Jordi Esteve, Alvaro Urbano-Ispizua, Carmen Martínez, Montserrat Rovira & Maria Queralt Salas

  4. Department of Medicine, University of Barcelona, Barcelona, Spain

    Luis F. Quintana, Laura Rosiñol, Jordi Esteve, Alvaro Urbano-Ispizua, Francesc Fernández-Avilés, Carmen Martínez & Montserrat Rovira

  5. Pharmacy Unit, Hospital Clínic de Barcelona, Barcelona, Spain

    Sonia Ruiz-Boy, Ester Carcelero, Paula Mate, Gisela Riu & Inés Monge

  6. Fundació i Institut de Recerca Josep Carreras contra la leucèmia (Campus Clínic), Barcelona, Spain

    Enric Carreras

Authors
  1. Marta Gómez-Hernando
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  2. Luis F. Quintana
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  18. Carmen Martínez
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  19. Montserrat Rovira
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  20. Maria Queralt Salas
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Contributions

MG and MQS designed the study, interpreted the results, and wrote the letter. MG collected the data and did the statistical analysis. LQ, MSL, NMC, AR, SR, EC, PM, GR, IMAS, MTS, LR, JE, AUI, EC, FFA, CM and MR provided valuable input into the study and reviewed and approved the manuscript.

Corresponding author

Correspondence to Maria Queralt Salas.

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The authors declare no competing interests.

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Gómez-Hernando, M., Quintana, L.F., Suárez-Lledo, M. et al. Hyponatremia induced by post-transplant cyclophosphamide in allogeneic hematopoietic cell transplantation. Bone Marrow Transplant 58, 212–214 (2023). https://doi.org/10.1038/s41409-022-01864-7

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  • DOI: https://doi.org/10.1038/s41409-022-01864-7

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