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Sequential high-sensitivity mutational and chimerism analyses predict responses to post-transplant salvage therapies in MDS

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Fig. 1: The clinical courses and molecular characteristics of four representative patients.

Data availability

All ddPCR data generated or analysed during this study are included in this published article, in its Supplementary material file.


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This study has been supported by grants from the Helsinki University Hospital Comprehensive Cancer Center and from the Southern Finland Regional Cancer Center (FICAN South). MiK received funding from the Finnish Cancer Institute, Finnish Medical Foundation and Cancer Society Finland. MM received funding from the Finnish Medical Foundation and the Finnish Cultural Foundation.

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Authors and Affiliations



FE was responsible for designing the study, compiled the clinical and molecular data and wrote the manuscript. JI recruited patients, followed their clinical courses and collected recipients of relapse interventions. MaK was responsible for designing Figs. 1, S1 and S2 and reviewing the molecular data. MiK was responsible for relapse treatments of patient 04. AP was responsible for follow-up patient samples from another hospital and reviewing the manuscript. LS was responsible for implementation of the study in the transplantation unit and recruiting patients and RN for the transplantation-related data of the patients. MM contributed to research discussion and data interpretation and wrote the manuscript. MM and JI performed the statistical analyses. SK was responsible for implementing the mutational and chimerism ddPCR analyses in HUSLAB as well as for NGS and collecting and reviewing the molecular data. All authors reviewed the manuscript during its preparation and approved the submission.

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Correspondence to Freja Ebeling.

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The authors declare no competing interests.

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Supplementary information


Supplementary information: Patient cohort, Methods, Statistics and Figure design, Table S3, Table S4, Table S5, Figure S1, Figure S2, Figure S3, Figure S4, Table S6

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Ebeling, F., Illman, J., Kankainen, M. et al. Sequential high-sensitivity mutational and chimerism analyses predict responses to post-transplant salvage therapies in MDS. Bone Marrow Transplant 58, 100–102 (2023).

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