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The effect of hematopoietic stem cell transplantation on fertility and strategies for improvement

Bone Marrow Transplantation volume 57, pages 1649–1656 (2022)Cite this article

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Abstract

Ovarian dysfunction is an important consequence of hematopoietic stem cell transplantation (HCT). Premature ovarian failure and infertility can severely impact the quality of life for the increasing number of female long-term survivors of HCT. Here, we review the impact of HCT on ovarian function, post-transplant fertility and birth outcomes, and the contemporaneous strategies to preserve fertility for these patients.

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The data contained in this review article is referenced in the reference section. No patients’ data were used for this review.

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Authors and Affiliations

  1. Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA

    Brittany File

  2. Department of Psychology, Tufts University, Boston, MA, USA

    Mia Gergis

  3. Department of Medical Oncology, Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, USA

    Usama Gergis

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Contributions

BF: Researched the topic and wrote the manuscript. MG: Contributed the sections on mechanisms of ovarian dysfunction. UG: Conceptualized the topic, contributed the sections on optimal conditioning regimens, and provided senior guidance. All authors approved the final version of the manuscript.

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Correspondence to Usama Gergis.

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File, B., Gergis, M. & Gergis, U. The effect of hematopoietic stem cell transplantation on fertility and strategies for improvement. Bone Marrow Transplant 57, 1649–1656 (2022). https://doi.org/10.1038/s41409-022-01792-6

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