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High incidence of resistant breakthrough invasive fungal infections (IFD) in patients treated for acute gastrointestinal graft-versus-host disease (GI GVHD) following allogeneic haematopoietic cell transplantation

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All data generated or analysed during this study are included in this published article and its supplementary appendix.

References

  1. Maertens JA. Invasive Fungal Infections. In: th, Carreras E, Dufour C, Mohty M, Kroger N, editors. The EBMT Handbook: Hematopoietic Stem Cell Transplantation and Cellular Therapies. Cham (CH). 2019, p. 273–80.

  2. Trifilio S, Singhal S, Williams S, Frankfurt O, Gordon L, Evens A, et al. Breakthrough fungal infections after allogeneic hematopoietic stem cell transplantation in patients on prophylactic voriconazole. Bone Marrow Transpl. 2007;40:451–6.

    CAS  Article  Google Scholar 

  3. Ullmann AJ, Lipton JH, Vesole DH, Chandrasekar P, Langston A, Tarantolo SR, et al. Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N. Engl J Med. 2007;356:335–47.

    CAS  Article  Google Scholar 

  4. De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis. 2008;46:1813–21.

    Article  Google Scholar 

  5. Donnelly JP, Chen SC, Kauffman CA, Steinbach WJ, Baddley JW, Verweij PE, et al. Revision and Update of the Consensus Definitions of Invasive Fungal Disease From the European Organization for Research and Treatment of Cancer and the Mycoses Study Group Education and Research Consortium. Clin Infect Dis. 2020;71:1367–76.

    Article  Google Scholar 

  6. Montesinos P, Rodriguez-Veiga R, Boluda B, Martinez-Cuadron D, Cano I, Lancharro A, et al. Incidence and risk factors of post-engraftment invasive fungal disease in adult allogeneic hematopoietic stem cell transplant recipients receiving oral azoles prophylaxis. Bone Marrow Transpl. 2015;50:1465–72.

    CAS  Article  Google Scholar 

  7. Biehl LM, Vehreschild JJ, Liss B, Franke B, Markiefka B, Persigehl T, et al. A cohort study on breakthrough invasive fungal infections in high-risk patients receiving antifungal prophylaxis. J Antimicrob Chemother. 2016;71:2634–41.

    Article  Google Scholar 

  8. Zeiser R, Blazar BR. Acute graft-versus-host disease—biologic process, prevention, and therapy. N. Engl J Med. 2017;377:2167–79.

    CAS  Article  Google Scholar 

  9. Labbe AC, Su SH, Laverdiere M, Pepin J, Patino C, Cohen S, et al. High incidence of invasive aspergillosis associated with intestinal graft-versus-host disease following nonmyeloablative transplantation. Biol Blood Marrow Transpl. 2007;13:1192–200.

    Article  Google Scholar 

  10. Matsumura-Kimoto Y, Inamoto Y, Tajima K, Kawajiri A, Tanaka T, Hirakawa T, et al. Association of cumulative steroid dose with risk of infection after treatment for severe acute graft-versus-host disease. Biol Blood Marrow Transpl. 2016;22:1102–7.

    CAS  Article  Google Scholar 

  11. Auberger J, Lass-Florl C, Aigner M, Clausen J, Gastl G, Nachbaur D. Invasive fungal breakthrough infections, fungal colonization and emergence of resistant strains in high-risk patients receiving antifungal prophylaxis with posaconazole: real-life data from a single-centre institutional retrospective observational study. J Antimicrob Chemother. 2012;67:2268–73.

    CAS  Article  Google Scholar 

  12. Riches ML, Trifilio S, Chen M, Ahn KW, Langston A, Lazarus HM, et al. Risk factors and impact of non-Aspergillus mold infections following allogeneic HCT: a CIBMTR infection and immune reconstitution analysis. Bone Marrow Transpl. 2016;51:322.

    CAS  Article  Google Scholar 

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Authors

Contributions

APS conceived of and designed the study. APS and all other co-authors contributed patient data through direct patient care. YY, PW and APS performed data collection and analysis, and wrote the manuscript. All authors reviewed and contributed to the final draft of the manuscript.

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Correspondence to Ashleigh P. Scott.

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Yuan, Y., Wong, P., Butler, J.P. et al. High incidence of resistant breakthrough invasive fungal infections (IFD) in patients treated for acute gastrointestinal graft-versus-host disease (GI GVHD) following allogeneic haematopoietic cell transplantation. Bone Marrow Transplant (2022). https://doi.org/10.1038/s41409-022-01773-9

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  • DOI: https://doi.org/10.1038/s41409-022-01773-9

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