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Ultrasonographic scoring system of late-onset sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 57, pages 1338–1340 (2022)Cite this article

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Sinusoidal obstruction syndrome (SOS)/veno-occlusive disease (VOD) is a potentially life-threatening complication after hematopoietic stem cell transplantation (HSCT) [1]. Late-onset SOS/VOD develops after 22 days posttransplant [2]. Late-onset SOS/VOD is diagnosed if the patient has hemodynamic and/or ultrasound evidence of SOS/VOD in addition to two clinical manifestations (painful hepatomegaly, >5% weight gain, and/or ascites).

We previously established US scoring systems for classical SOS/VOD: the Hokkaido US-based scoring system (HokUS-10) [3] and the refined HokUS-6 [4]. However, their utility for late-onset SOS/VOD remained to be clarified. We herein evaluated the efficacy of HokUS-10 and 6 to diagnose late-onset SOS/VOD.

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Fig. 1: Description of late-onset SOS patients and HokUS-10/6 diagnosis.

Data availability

The data sets generated during and/or analysed during the current study are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Diagnostic Center for Sonography, Hokkaido University Hospital, Sapporo, Japan

    Mutsumi Nishida, Takahito Iwai, Megumi Sato, Yusuke Kudo, Satomi Omotehara, Tatsunori Horie, Ryosuke Sakano & Takanori Teshima

  2. Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Japan

    Junichi Sugita, Takahito Iwai, Yusuke Kudo, Satomi Omotehara, Yuta Hasegawa, Atsushi Yasumoto & Takanori Teshima

  3. Department of Radiological Technology, Hokkaido University Hospital, Sapporo, Japan

    Megumi Sato, Tatsunori Horie & Ryosuke Sakano

  4. Department of Pediatrics, Hokkaido University Faculty of Medicine, Sapporo, Japan

    Yuko Cho

  5. Department of Hematology, Hokkaido University Faculty of Medicine, Sapporo, Japan

    Takanori Teshima

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  1. Mutsumi Nishida
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  2. Junichi Sugita
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Contributions

MN participated in the research design, writing of the paper, performing the research and data analysis. JS, AY, and YH participated in research design, data analysis and review of the paper. TI, MS, YK, SO, TH, and RS participated in performing the research. YC participated in the review of the paper. TT participated in the research design, data analysis and writing and review of the paper.

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Correspondence to Mutsumi Nishida.

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Nishida, M., Sugita, J., Iwai, T. et al. Ultrasonographic scoring system of late-onset sinusoidal obstruction syndrome/veno-occlusive disease after hematopoietic stem cell transplantation. Bone Marrow Transplant 57, 1338–1340 (2022). https://doi.org/10.1038/s41409-022-01717-3

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