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Predictive value of next-generation sequencing-based minimal residual disease after CAR-T cell therapy

Bone Marrow Transplantation volume 57, pages 1350–1353 (2022)Cite this article

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Fig. 1: MRD detection and clinical outcomes of patients treated with CAR-T cells.

Data availability

All data generated or analyzed during this study are included in this published article (and its Supplementary Information files).

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Acknowledgements

This work was supported by the 973 Program (Project No. 2015-CB964900), the Natural Science Foundation of China (Project No. 81770201 and No. 81730008). This trial was registered at www.chictr.org.cn as # ChiCTR1800018468 and # ChiCTR-OCC-15007008.

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Author notes

  1. These authors contributed equally: Yue Huang, Houli Zhao, Mi Shao

Authors and Affiliations

  1. Bone Marrow Transplantation Center, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China

    Yue Huang, Houli Zhao, Mi Shao, Linghui Zhou, Xiaoqing Li, Guoqing Wei, Wenjun Wu, Jiazhen Cui, Yongxian Hu & He Huang

  2. Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China

    Yue Huang, Houli Zhao, Mi Shao, Linghui Zhou, Xiaoqing Li, Guoqing Wei, Wenjun Wu, Jiazhen Cui, Yongxian Hu & He Huang

  3. Institute of Hematology, Zhejiang University, Hangzhou, China

    Yue Huang, Houli Zhao, Mi Shao, Linghui Zhou, Xiaoqing Li, Guoqing Wei, Wenjun Wu, Jiazhen Cui, Yongxian Hu & He Huang

  4. Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, China

    Yue Huang, Houli Zhao, Mi Shao, Linghui Zhou, Xiaoqing Li, Guoqing Wei, Wenjun Wu, Jiazhen Cui, Yongxian Hu & He Huang

  5. Shanghai YaKe Biotechnology Ltd, Shanghai, China

    Alex H. Chang

  6. Hangzhou ImmuQuad Biotech, LLC., Hangzhou, China

    Tao Sun

  7. Institute of Wenzhou, Zhejiang University, Wenzhou, China

    Tao Sun

Authors
  1. Yue Huang
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Contributions

YH, HZ and MS collected the patients’ data and drafted the manuscript. TS, YXH and HH conceived and designed the study. YXH revised the manuscript along with GW, WW and AHC and these individuals were responsible for the treatment of these patients. All authors checked and approved the final manuscript.

Corresponding authors

Correspondence to Tao Sun, Yongxian Hu or He Huang.

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Huang, Y., Zhao, H., Shao, M. et al. Predictive value of next-generation sequencing-based minimal residual disease after CAR-T cell therapy. Bone Marrow Transplant 57, 1350–1353 (2022). https://doi.org/10.1038/s41409-022-01699-2

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  • DOI: https://doi.org/10.1038/s41409-022-01699-2

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