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Efficacy and safety of CAR-T cell therapy in minorities

Bone Marrow Transplantation volume 57, pages 1187–1190 (2022)Cite this article

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Fig. 1: Outcomes for minority and non-minority patients receiving CAR-T cell therapy.

Data availability

Data can be available upon request to the corresponding author.

References

  1. Neelapu SS, Locke FL, Bartlett NL, Lekakis LJ, Miklos DB, Jacobson CA, et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N Engl J Med. 2017;377:2531–44. https://doi.org/10.1056/NEJMoa1707447.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Wang M, Munoz J, Goy A, Locke FL, Jacobson CA, Hill BT, et al. KTE-X19 CAR T-cell therapy in relapsed or refractory mantle-cell lymphoma. N Engl J Med. 2020;382:1331–42. https://doi.org/10.1056/NEJMoa1914347.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Shah BD, Ghobadi A, Oluwole OO, Logan AC, Boissel N, Cassaday RD, et al. KTE-X19 for relapsed or refractory adult B-cell acute lymphoblastic leukaemia: phase 2 results of the single-arm, open-label, multicentre ZUMA-3 study. Lancet. 2021;398:491–502. https://doi.org/10.1016/s0140-6736(21)01222-8.

    Article  CAS  PubMed  Google Scholar 

  4. Schuster SJ, Bishop MR, Tam CS, Waller EK, Borchmann P, McGuirk JP, et al. Tisagenlecleucel in adult relapsed or refractory diffuse large B-cell lymphoma. N Engl J Med. 2018;380:45–56. https://doi.org/10.1056/NEJMoa1804980.

    Article  PubMed  Google Scholar 

  5. Abramson JS, Palomba ML, Gordon LI, Lunning MA, Wang M, Arnason J, et al. Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study. Lancet. 2020;396:839–52. https://doi.org/10.1016/s0140-6736(20)31366-0.

    Article  CAS  PubMed  Google Scholar 

  6. Maude SL, Laetsch TW, Buechner J, Rives S, Boyer M, Bittencourt H, et al. Tisagenlecleucel in children and young adults with B-cell lymphoblastic leukemia. N Engl J Med. 2018;378:439–48. https://doi.org/10.1056/NEJMoa1709866.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Locke FL, Miklos DB, Jacobson CA, Perales MA, Kersten MJ, Oluwole OO, et al. Axicabtagene ciloleucel as second-line therapy for large B-cell lymphoma. N Engl J Med. 2021. https://doi.org/10.1056/NEJMoa2116133.

    Article  PubMed  Google Scholar 

  8. Majhail NS, Nayyar S, Santibañez ME, Murphy EA, Denzen EM. Racial disparities in hematopoietic cell transplantation in the United States. Bone Marrow Transpl. 2012;47:1385–90. https://doi.org/10.1038/bmt.2011.214.

    Article  CAS  Google Scholar 

  9. Tao L, Foran JM, Clarke CA, Gomez SL, Keegan TH. Socioeconomic disparities in mortality after diffuse large B-cell lymphoma in the modern treatment era. Blood. 2014;123:3553–62. https://doi.org/10.1182/blood-2013-07-517110.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Griffiths R, Gleeson M, Knopf K, Danese M. Racial differences in treatment and survival in older patients with diffuse large B-cell lymphoma (DLBCL). BMC Cancer. 2010;10:625 https://doi.org/10.1186/1471-2407-10-625.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Shenoy PJ, Malik N, Nooka A, Sinha R, Ward KC, Brawley OW, et al. Racial differences in the presentation and outcomes of diffuse large B-cell lymphoma in the United States. Cancer. 2011;117:2530–40. https://doi.org/10.1002/cncr.25765.

    Article  PubMed  Google Scholar 

  12. Peravali M, Gomes-Lima C, Tefera E, Baker M, Sherchan M, Farid S, et al. Racial disparities in immune-related adverse events of immune checkpoint inhibitors and association with survival based on clinical and biochemical responses. World J Clin Oncol. 2021;12:103–14. https://doi.org/10.5306/wjco.v12.i2.103.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We would like to acknowledge all the physician assistants and nurses on the bone marrow transplant and cellular therapy unit for their compassionate care for these patients. These studies were supported by grants from Izzy Englander, Jane and Myles Dempsey Family, Bristol Myers Squibb Foundation Diversity in Clinical Trials Career Development Program and the Leukemia and Lymphoma Society.

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Author notes

  1. These authors contributed equally: Astha Thakkar, Michelly Abreu, Ira Braunschweig, Mendel Goldfinger.

Authors and Affiliations

  1. Department of Oncology, Montefiore Einstein Cancer Center, Blood Cancer Institute, Montefiore Medical Center, Bronx, New York, NY, USA

    Astha Thakkar, Michelly Abreu, R. Alejandro Sica, Aditi Shastri, Noah Kornblum, Nishi Shah, Ioannis Mantzaris, Kira Gritsman, Eric Feldman, Richard Elkind, Amit Verma, Ira Braunschweig & Mendel Goldfinger

  2. Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, NY, USA

    Kith Pradhan

  3. Montefiore Health System, Bronx, New York, NY, USA

    Susan Green-Lorenzen

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  1. Astha Thakkar
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Contributions

Conception and design: AT, MG, AV, Data collection: MA, AT, Statistical analysis: KP, Initial manuscript draft: AT, MG, Manuscript revision: All authors. All authors have reviewed and approved the final version of the manuscript.

Corresponding authors

Correspondence to Ira Braunschweig or Mendel Goldfinger.

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Competing interests

AV has received research funding from Prelude, BMS, GSK, Incyte, Medpacto, Curis and Eli Lilly and is a scientific advisor for Stelexis, Novartis, Acceleron and Celgene and received honoraria from Stelexis and Janssen and holds equity in Stelexis and Throws Exception. KG has received research funding from ionctura, SA and ADC therapeutics. AS has received honorarium from GLG, Guidepoint, Onclive, consultation fee from Janssen Pharmaceuticals, advisory board fee from Rigel Pharmaceuticals, research funding from Kymera Therapeutics. AT, MA, KP, RAS, NK, NS, IM, EF, SGL, RE, IB and MG have nothing to disclose.

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Thakkar, A., Abreu, M., Pradhan, K. et al. Efficacy and safety of CAR-T cell therapy in minorities. Bone Marrow Transplant 57, 1187–1190 (2022). https://doi.org/10.1038/s41409-022-01670-1

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