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Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT

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Fig. 1: Correlation of patient age and T cell features.
Fig. 2: Association of systemic T cell characteristics with baseline variables and survival.

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Acknowledgements

The authors wish to thank all participating centres and technical staff. SH and GØJ are funded by scholarships from Rigshospitalet’s Research Fund. Reagents were supported by supported by a grant from Region Hovedstadens’ Research Foundation. This study was furthermore supported by grants from The Denmark-America Fund, Dagmar Marshalls Fund, The Danish Cancer Society, Reinholdt W. Jorks Fund, A.P. Møller Fund (Lægefonden), Sejer Persson & Lis Klüwer Persson’s Fund. SH and KG are also funded by the Novo Nordisk Foundation (Novo Nordisk Foundation Center for Stem Cell Biology, DanStem; grant NNF17CC0027852). The project is part of the Danish Research Center for Precision Medicine in Blood Cancers funded by the Danish Cancer Society grant no. R223-A13071.

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SH, GØJ, and KG conceived the study, CN, BS, LHE, JB, EKH provided patient samples, SH, PJ, MT, TCE, PB, TSL provided clinical data, GØJ, SH, FGR-G, JSJ performed the analyses, SH, GØJ, FF, TSL, JW, KG analyzed the data, SH, GØJ wrote the manuscript; and all authors participated in interpretation of data, manuscript writing, and review of the manuscript.

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Correspondence to Simon Husby.

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Husby, S., Jørgensen, G.Ø., Favero, F. et al. Level of unique T cell clonotypes is associated with clonal hematopoiesis and survival in patients with lymphoma undergoing ASCT. Bone Marrow Transplant 57, 674–677 (2022). https://doi.org/10.1038/s41409-022-01580-2

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