Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Infectious complications in adult sickle cell anemia patients undergoing hematopoietic stem cell transplantation

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Howard J. Sickle cell disease: when and how to transfuse. Hematol Am Soc Hematol Educ Program. 2016;2016:625–31.

    Article  Google Scholar 

  2. 2.

    Bhatia M, Sheth S. Hematopoietic stem cell transplantation in sickle cell disease: patient selection and special considerations. J Blood Med. 2015;6:229–38.

    PubMed  PubMed Central  Google Scholar 

  3. 3.

    Walters MC, Hardy K, Edwards S, Adamkiewicz T, Barkovich J, Bernaudin F, et al. Pulmonary, gonadal, and central nervous system status after bone marrow transplantation for sickle cell disease. Biol Blood Marrow Transpl. 2010;16:263–72.

    Article  Google Scholar 

  4. 4.

    Fitzhugh CD, Cordes S, Taylor T, Coles W, Roskom K, Link M, et al. At least 20% donor myeloid chimerism is necessary to reverse the sickle phenotype after allogeneic HSCT. Blood. 2017;130:1946–8.

    CAS  Article  Google Scholar 

  5. 5.

    Busca A, Locatelli F, Barbui A, Ghisetti V, Cirillo D, Serra R, et al. Infectious complications following nonmyeloablative allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2003;5:132–9.

    CAS  Article  Google Scholar 

  6. 6.

    Alzahrani M, Damlaj M, Jeffries N, Alahmari B, Singh A, Rondelli D, et al. Non-myeloablative human leukocyte antigen-matched related donor transplantation in sickle cell disease: outcomes from three independent centres. Br J Haematol. 2021;192:761–8.

    CAS  Article  Google Scholar 

  7. 7.

    Hsieh MM, Fitzhugh CD, Weitzel RP, Link ME, Coles WA, Zhao X, et al. Nonmyeloablative HLA-matched sibling allogeneic hematopoietic stem cell transplantation for severe sickle cell phenotype. JAMA 2014;312:48–56.

    Article  Google Scholar 

  8. 8.

    Damlaj M, Khalid F, Alahmari B, Alaskar A, Ghazi S, Johani S, et al. Optimal pre-emptive cytomegalovirus therapy threshold in a patient population with high prevalence of seropositive status. Curr Res Transl Med. 2020;68:131–7.

    Article  Google Scholar 

  9. 9.

    Liu J, Bian Z, Wang X, Xu LP, Fu Q, Wang C, et al. Inverse correlation of Vdelta2(+) T-cell recovery with EBV reactivation after haematopoietic stem cell transplantation. Br J Haematol. 2018;180:276–85.

    CAS  Article  Google Scholar 

  10. 10.

    De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, et al. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) Consensus Group. Clin Infect Dis. 2008;46:1813–21.

    Article  Google Scholar 

  11. 11.

    Brown RA, Herzig RH, Wolff SN, Frei-Lahr D, Pineiro L, Bolwell BJ, et al. High-dose etoposide and cyclophosphamide without bone marrow transplantation for resistant hematologic malignancy. Blood. 1990;76:473–9.

    CAS  Article  Google Scholar 

  12. 12.

    Kamboj M, Son C, Cantu S, Chemaly RF, Dickman J, Dubberke E, et al. Hospital-onset Clostridium difficile infection rates in persons with cancer or hematopoietic stem cell transplant: a C3IC network report. Infect Control Hosp Epidemiol. 2012;33:1162–5.

    Article  Google Scholar 

  13. 13.

    Martin SI, Marty FM, Fiumara K, Treon SP, Gribben JG, Baden LR. Infectious complications associated with alemtuzumab use for lymphoproliferative disorders. Clin Infect Dis. 2006;43:16–24.

    CAS  Article  Google Scholar 

  14. 14.

    Kanda Y, Oshima K, Kako S, Fukuda T, Uchida N, Miyamura K, et al. In vivo T-cell depletion with alemtuzumab in allogeneic hematopoietic stem cell transplantation: Combined results of two studies on aplastic anemia and HLA-mismatched haploidentical transplantation. Am J Hematol. 2013;88:294–300.

    CAS  Article  Google Scholar 

  15. 15.

    Chakrabarti S, Mackinnon S, Chopra R, Kottaridis PD, Peggs K, O’Gorman P, et al. High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution. Blood. 2002;99:4357–63.

    CAS  Article  Google Scholar 

  16. 16.

    Rebello P, Cwynarski K, Varughese M, Eades A, Apperley JF, Hale G. Pharmacokinetics of CAMPATH-1H in BMT patients. Cytotherapy, 2001;3:261–7.

    CAS  Article  Google Scholar 

  17. 17.

    Bhatt ST, Bednarski JJ, Berg J, Trinkaus K, Murray L, Hayashi R, et al. Immune reconstitution and infection patterns after early alemtuzumab and reduced intensity transplantation for nonmalignant disorders in pediatric patients. Biol Blood Marrow Transpl. 2019;25:556–61.

    CAS  Article  Google Scholar 

  18. 18.

    King AA, Kamani N, Bunin N, Sahdev I, Brochstein J, Hayashi RJ, et al. Successful matched sibling donor marrow transplantation following reduced intensity conditioning in children with hemoglobinopathies. Am J Hematol. 2015;90:1093–8.

    CAS  Article  Google Scholar 

  19. 19.

    Park SH, Choi SM, Lee DG, Choi JH, Yoo JH, Kim SH, et al. Infectious complications associated with alemtuzumab use for allogeneic hematopoietic stem cell transplantation: comparison with anti-thymocyte globulin. Transpl Infect Dis. 2009;11:413–23.

    CAS  Article  Google Scholar 

  20. 20.

    Fisher A, Seguel JM, de la Torre AN, Wilson D, Merchant A, Arora RK, et al. Effect of sirolimus on infection incidence in liver transplant recipients. Liver Transpl. 2004;10:193–8.

    Article  Google Scholar 

Download references

Author information




KAA: Conceptualization, Methodology, Data acquisition, Writing—Original draft preparation. MD: Conceptualization, Formal analysis, Writing—Reviewing and editing. MB: Conceptualization, Methodology, Writing—Reviewing and editing. SA, HA, RMR, RA, and NA: Conceptualization, Data acquisition, Writing-Reviewing and editing. BA, AA, AA, MA: Writing—Reviewing and editing.

Corresponding author

Correspondence to Khadega A. Abuelgasim.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Abuelgasim, K.A., Damlaj, M., Bosaeed, M. et al. Infectious complications in adult sickle cell anemia patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplant (2021).

Download citation


Quick links